Phân tích các vấn đề liên quan đến thuốc trên bệnh nhân ung thư điều trị hoá chất: Nghiên cứu cắt ngang tại một bệnh viện chuyên khoa ung bướu tuyến tỉnh tại Việt Nam=Drug-related problems in cancer patients undergoing chemotherapy: a hospital based cross-sectional study in Viet Nam

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Tác giả: Văn Thắng Mai, Thị Hồng Hạnh Nguyễn, Thị Liên Hương Nguyễn, Trường Giang Nguyễn, Tuấn Minh Nguyễn, Văn Thành Nguyễn, Văn Tú Nguyễn, Thị Thu Trang Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.270-278

Bộ sưu tập: Metadata

ID: 478158

Thêm vào giỏ

Phân loại, đánh giá mức độ đồng thuận và mức độ ý nghĩa của các vấn đề liên quan đến thuốc (Drug-related problem, DRP) trong kê đơn thuốc điều trị ung thư. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên các DRP đã được phát hiện và có can thiệp dược lâm sàng trong quá trình xem xét sử dụng thuốc thường quy trên bệnh nhân điều trị hoá trị tại một bệnh viện Ung Bướu tuyến tỉnh từ tháng 01/2022 đến tháng 6/2023. DRP được phân loại theo Hướng dẫn của Bộ Y tế và được lấy ý kiến của nhóm chuyên gia tại bệnh viện về (1) mức độ đồng thuận theo thang Likert 5 (từ không đồng ý đến hoàn toàn đồng ý)
(2) mức độ ý nghĩa (đáng kể, trung bình, và không đáng kể). Kết quả: Trong nghiên cứu ghi nhân có 310 DRP trên 265 bệnh nhân với 265 đợt điều trị. Số DRP trung bình/đợt là 1,17 và số đợt có 1 DRP chiếm 83,4%. DRP chủ yếu liên quan đến hoá chất, ghi nhân 205 DRP chiếm 66,1%. DRP về liều dùng chiếm tỷ lệ lớn nhất, gặp ở 98 (31,6%) bệnh nhân. Có 84,5% chuyên gia hoàn toàn đ ồng ý với các DRP và 62,5% chuyên gia đánh giá DRP ở mức ý nghĩa trung bình. Kết luận: Cần đẩy mạnh hoạt động dược lâm sàng để hạn chế DRP.To classify and evaluate the level of consensus and significance of drug-related problems (DRPs) in cancer treatment prescriptions. Methods: A cross-sectional study was conducted on DRPs detected and intervened by clinical pharmacists during routine medication reviews for cancer patients undergoing chemotherapy at a provincial oncology hospital in Vietnam from January 2022 to June 2023. DRPs were classified according to the Ministry of Health guidelines and reviewed by a group of hospital experts regarding (1) the consensus level, using a 5-point Likert scale (from disagree to completely agree)
(2) the level of clinical significance (significant, moderate, and insignificant). Results: A total of 310 DRPs were recorded across 265 treatment cycles in 265 cancer patients, with an average of 1.17 DRPs per cycle. Cycles with 1 DRP accounted for 83.4%. Most DRPs were related to chemotherapy (205 DRPs- 61.6%), with dosage-related DRPs being the most common, occurring in 98 patients (31.6%)
84.5% of experts completely agreed with the DRPs and 62.5% of experts rated the DRPs at the moderate clinical significance level. Conclusion: It is essential to promote clinical pharmacy activities to reduce DRPs.

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