Tình hình đề kháng kháng sinh, sự phân bố của các lớp Ambler A, B, D của Pseudomonas aeruginosa sinh carbapenemase và mối liên quan với các gen mã hóa carbapenemase tại Bệnh viện Nhi Đồng 2=Antibiotic resistance, distribution of Ambler classes A, B, and D in carbapenemaseproducing Pseudomonas aeruginosa, and the correlation with carbapenemaseencoding genes at Children's Hospital 2

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Tác giả: Thị Thanh Thùy Lê, Thùy An Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.91-97

Bộ sưu tập: Metadata

ID: 478192

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Phân tích tình hình đề kháng kháng sinh của Pseudomonas aeruginosa sinh men carbapenemase, tỷ lệ phân bố các lớp Ambler A, B, D sinh carbapenemase trên hệ thống Phoenix M50 và mối liên quan giữa các gen mã hóa carbapenemase với việc phân bố các lớp Ambler này. Phương pháp: Nghiên cứu cắt ngang mô tả, được thực hiện tại Bệnh viện Nhi Đồng 2 trong thời gian từ tháng 15/09/2023 đến tháng 31/05/2024. Kết quả: P. aeruginosa sinh men carbapenemase có tỷ lệ kháng rất cao với kháng sinh nhóm β-lactam như cefepime (82,3%), ceftazidime (89,5%), và ceftazidime-avibactam (71,8%), imipenem (96,0%) và meropenem (97,6%) và cũng cao đối với nhóm aminoglycoside như gentamicin (79%) và amikacin (41,1%). Tỷ lệ P. aeruginosa sinh men carbapenemase thuộc lớp B cao nhất với 73,39% và blaNDM-1 chiếm ưu thế với tỷ lệ 67,74%. Đặc biệt khi phân tích mối tương quan và phân bố các lớp Ambler, blaNDM-1 phổ biến nhất trong lớp B với 83,5% trong khi blaIMP chiếm 16,5%. Kết luận: Tất cả các kháng sinh của P. aeruginosa sinh men carbapenemase đều có tỷ lệ đề kháng cao hơn P. aeruginosa không sinh men carbapenemase, sự khác biệt này có ý nghĩa thống kê với p <
0,001. P. aeruginosa sinh men carbapenemase, đặc biệt thuộc lớp B với blaNDM-1 chiếm ưu thế, có vai trò quan trọng trong việc làm gia tăng mức độ kháng kháng sinh.To analyze the antibiotic resistance profile of Pseudomonas aeruginosa producing carbapenemase, the distribution of Ambler class A, B, and D carbapenemaseproducing strains identified by the Phoenix M50 system, and the correlation between carbapenemase-encoding genes and the distribution of Ambler classes. Methods: A cross-sectional descriptive study conducted at Children’s Hospital 2 from September 15, 2023, to May 31, 2024. Results: Carbapenemase-producing P. aeruginosa exhibited a high resistance rate to β-lactam antibiotics such as cefepime (82.3%), ceftazidime (89.5%), and ceftazidime-avibactam (71.8%), as well as imipenem (96.0%) and meropenem (97.6%). High resistance was also observed in aminoglycosides, with gentamicin (79%) and amikacin (41.1%). Among the carbapenemase-producing strains, those belonging to Ambler class B were the most prevalent, accounting for 73.39%, with the blaNDM-1 gene being dominant at 67.74%. Notably, when analyzing the correlation and distribution of Ambler classes, blaNDM-1 gene was the most common in class B, representing 83.5%, while blaIMP accounted for 16.5%. Conclusion: Carbapenemase-producing P. aeruginosa exhibited significantly higher antibiotic resistance compared to noncarbapenemase- producing strains, with a statistically significant difference (p <
0.001). Class B carbapenemase-producing P. aeruginosa, particularly those carrying the blaNDM-1 gene, plays a crucial role in increasing antibiotic resistance levels.

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