Một số yếu tố liên quan đến hiệu quả phương pháp điều trị cắt lách ở bệnh nhân giảm tiểu cầu miễn dịch nguyên phát kháng trị=Some factors related to the results of splenectomy treatment of patients with refractory idiopathic thrombocytopenia purpura (ITP) at the National Institute of Hematology and Blood Transfusion (NIHBT), from 2019 to 2023

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Sinh Huy Đặng, Thị Thảo Nguyễn, Quang Hoà Phan, Thị Tươi Trần, Thị Vân Trần, Đình Hùng Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.116-124

Bộ sưu tập: Metadata

ID: 478223

Thêm vào giỏ

Describe some factors related to the results of splenectomy treatment of ITP patients at the NIHBT period 2019-2023. Subjects and methods: 49 patients with refractory ITP over 15 years old treated with splenectomy, treated at NIHBT from 2019 to 2023. The research method is retrospective and prospective descriptive research combined with patient interviews according to the research medical record form. Results: The overall response rate was 83.3% (CR 45.8%, PR 37.5%), NR was 16.7%. Sustain response at 12 months was 72.2%. After 1 month of splenectomy and 12 months of splenectomy, the 30-50 age group has higher response rate. Age >
50 was the least responsive, but the difference was not statistically significant. The response rate in male patients is lower than that in female. The difference is most obvious immediately after splenectomy. The time from diagnosis to splenectomy after 6 months has better response results than that before 6 months. Patients who didn’t respond immediately after splenectomy within 2 weeks are closely related to no long-term response. Patients who was good respond immediately after splenectomy had very good long-term response results. Conclusion: Factors have been associated with a good response to splenectomy: female patients, age 30–50 years and 6 months after splenectomy. A good response within 2 weeks of splenectomy is strongly associated with a durable response.Mô tả một số yếu tố liên quan đến kết quả điều trị cắt lách của bệnh nhân (BN) Giảm tiểu cầu miễn dịch nguyên phát (ITP) tại Viện Huyết Học truyền máu TW, giai đoạn 2019-2023. Đối tượng nghiên cứu và phương pháp nghiên cứu: 49 bệnh nhân ITP kháng trị trên 15 tuổi có điều trị bằng phương pháp cắt lách, điều trị tại Viện Huyết học truyền máu TW từ năm 2019-2023. Phương pháp nghiên cứu: mô tả hồi cứu và tiến cứu, theo dõi dọc Kết quả nghiên cứu: Tỷ lệ đáp ứng chung của nhóm nghiên cứu 83,3% (đáp ứng hoàn toàn (CR) 45,8 %, đáp ứng một phần (PR) 37,5%), không đáp ứng (NR) chiếm 16,7%. Đáp ứng lâu bền tại thời điểm 12 tháng 72,2%. Tìm hiểu mối liên quan các yếu tố ảnh hưởng đến kết quả cắt lách chúng tôi thấy: Xét tại các thời điểm ngay sau cắt lách, cắt lách 1 tháng và cắt lách 12 tháng, nhóm tuổi 30-50 có tỷ lệ đáp ứng cao nhất, tuổi >
50 kém đáp ứng nhất nhưng sự khác biệt chưa có ý nghĩa thống kê. Tỷ lệ đáp ứng điều trị cắt lách ở bệnh nhân nam thấp hơn nữ. Sự khác biệt rõ rệt nhất ngay sau cắt lách. Thời gian từ chẩn đoán đến cắt lách sau 6 tháng có kết quả đáp ứng lâu bền tốt hơn trước 6 tháng, Bệnh nhân không đạt đáp ứng ngay sau cắt lách trong 2 tuần liên quan chặt chẽ với kết quả không đáp ứng cắt lách. Các bệnh nhân đáp ứng tốt, ổn định ngay sau cắt lách 2 tuần có kết quả đáp ứng lâu dài rất tốt. Kết luận: Một số yếu tố liên quan đến đáp ứng tốt với cắt lách bao gồm bệnh nhân nữ, tuổi 30-50, thời gian cắt lách sau 6 tháng. Bệnh nhân đáp ứng tốt ngay trong 2 tuần sau cắt lách liên quan chặt chẽ với đáp ứng lâu bền.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR