Bước đầu đánh giá kết quả điều trị bệnh bạch cầu cấp lympho ở trẻ em theo phác đồ FRALLE 2000 tại bệnh viện Huyết học – Truyền máu Cần Thơ=Initial evaluation of acute lymphoblastic leukemia treatment in children according to the FRALLE 2000 protocol at Cantho Hematology

Bước đầu đánh giá kết quả điều trị bệnh bạch cầu cấp lympho ở trẻ em theo phác đồ FRALLE 2000 tại bệnh viện Huyết học – Truyền máu Cần Thơ=Initial evaluation of acute lymphoblastic leukemia treatment in children according to the FRALLE 2000 protocol at Cantho Hematology - Blood Transfusion hospital

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Tác giả: Hùng Minh Cao, Xuân Việt Nguyễn, Văn Nghĩa Phạm, Ngọc Châu Trần, Lê Minh Hiển Trương

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.152-159

Bộ sưu tập: Báo, Tạp chí

ID: 478227

Thêm vào giỏ

Acute lymphocytic leukemia is the most common cancer in children, accounting for approximately 80% of all acute leukemias in children. Currently, the diagnosis, treatment and monitoring of treatment response for acute lymphoblastic leukemia patients has made great progress. After a period of implementing FRALLE 2000 chemotherapy regimen at Can Tho Hematology and Blood Transfusion Hospital, we evaluated the results to contribute to improving treatment in the future. Menthod: A retrospective case series of 56 acute lymphocytic leukemia patients receiving chemotherapy with FRALLE 2000 protocol at Can Tho Hospital of Hematology and Blood Transfusion from 01/2017-8/2022. Result: The response rate after induction was 100%. The mean overall survival time was 38 ± 2,7 months. The probability of overall survival at 12th month was 92,1 ± 5,4%, at 24th month and 36th month was 78,2 ± 8,7%. The mean of disease-free survival was 34 ± 3,5 month. The probability of disease-free survival at 12th month and 24th month was 80 ± 8%, at 36th month was 51 ± 17,6%. Conclusion: The effect of the FRALLE 2000 protocol on acute lymphocytic leukemia patients help them improve their OS and DFS.Bệnh bạch cầu cấp dòng lympho là bệnh lý ác tính thường gặp nhất ở trẻ em, chiếm khoảng 80% trong các bệnh bạch cầu cấp ở trẻ em. Hiện nay, việc chẩn đoán, điều trị và theo dõi đáp ứng điều trị đối với bệnh trẻ em bạch cầu cấp dòng lympho có những tiến bộ vượt bậc. Sau một thời gian triển khai hóa trị phác đồ FRALLE 2000 tại bệnh viện Huyết học – Truyền máu Cần Thơ, chúng tôi tiến hành đánh giá kết quả để góp phần cải tiến điều trị trong thời gian tới. Đối tượng, phương pháp: Báo cáo loạt ca hồi cứu 56 bệnh trẻ em bạch cầu cấp dòng lympho được hóa trị phác đồ FRALLE 2000 tại bệnh viện Huyết học - Truyền máu Cần Thơ từ 01/2017-8/2022. Kết quả: Tỷ lệ lui bệnh hoàn toàn sau điều trị tấn công phác đồ FRALLE 2000 là 100%. Thời gian sống toàn bộ trung bình là 38 ± 2,7 tháng. Xác suất sống thêm toàn bộ tại thời điểm 12 tháng là 92,1 ± 5,4%, 24 tháng và 36 tháng là 78,2 ± 8,7%. Thời gian sống không bệnh trung bình là 34 ± 3,5 tháng. Xác suất sống thêm không bệnh tại thời điểm 12 tháng, 24 tháng là 80 ± 8%, 36 tháng là 51 ± 17,6%. Kết luận: Phác đồ FRALLE 2000 là phác đồ điều trị có hiệu quả, thời gian sống kéo dài trên bệnh bạch cầu cấp lympho trẻ em tại bệnh viện Huyết học - Truyền máu Cần Thơ.

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