Một số đặc điểm lâm sàng, xét nghiệm ở bệnh nhi lơ xê mi cấp dòng tủy điều trị tại Viện Huyết học - Truyền máu Trung ương=Clinical and testing features in pediatric patients with acute myeloid leukemia treated at the National Institute of Hematology and Blood Transfusion

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Tác giả: Thị Hưng Dương, Thị Hồng Hoàng, Lan Mai, Hà Thanh Nguyễn, Thị Ngãi Nguyễn, Thị Thư Nguyễn, Quỳnh Mai Trần, Thanh Tùng Trần, Thu Thủy Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.185-195

Bộ sưu tập: Metadata

ID: 478233

Thêm vào giỏ

Describe clinical characteristics and describe laboratory characteristics of pediatric patients with acute myeloid leukemia treated at the National Institute of Hematology and Blood Transfusion in the period 2019-2022. Research subjects: 148 pediatric patients with acute myeloid leukemia, hospitalized at the National Institute of Hematology and Blood Transfusion in 4 years (2019-2022). Research method: cross-sectional description. Results: The ratio of male/female patients with acute myeloid leukemia was about 1.2/1
the average age was 8.4 years. Anemia, bleeding and infection were common symptoms. 58.11% of patients had at least 1 of the 3 symptoms of liver/spleen/lymph node enlargement
8.78% of patients had central nervous system infiltration. Acute myeloid leukemia M4 and M2 had the highest rates, 41.9% and 35.8%, respectively. CD33, MPO, CD13 were positive markers with high rates, 95.9%, 78.4% and 51.4%, respectively. 47.3% of patients had chromosomal abnormalities, the most common being t(8
21) accounting for 33.3%. AML-ETO hybrid gene accounted for 28.95%
FLT3-ITD mutation was found in 14.17%. Conclusion: Acute myeloid leukemia in children, the group of patients ≥10 years old has a high rate (39.9%)
Male/female ratio is 1.2/1
most have anemia (93.9%)
8.78% of patients have central nervous system infiltration. Acute myeloid leukemia M4 and M2 have a high rate (41.9% and 35.8%), most patients have increased marrow cell density (68.2%). 47.3% of patients have chromosomal abnormalities. The most common abnormalities are t(8
21), -Y, trisomy 8. AML-ETO hybrid gene and FLT3-ITD mutation are found at high rates (28.95% and 14.17%).Mô tả đặc điểm lâm sàng và mô tả đặc điểm xét nghiệm bệnh nhi lơ xê mi cấp dòng tủy điều trị tại Viện Huyết học - Truyền máu Trung ương giai đoạn 2019-2022. Đối tượng nghiên cứu: 148 bệnh nhi Lơ xê mi cấp dòng tủy, nhập viện điều trị tại Viện Huyết học- Truyền máu Trung ương trong 4 năm (2019- 2022). Phương pháp nghiên cứu: Mô tả cắt ngang. Kết quả: Tỷ lệ bệnh nhi nam/nữ mắc LXM cấp dòng tủy khoảng 1,2/1
độ tuổi trung bình 8,4 tuổi. Thiếu máu, xuất huyết và nhiễm khuẩn là những triệu chứng phổ biến. 58,11% bệnh nhân gặp ít nhất 1 trong 3 triệu chứng gan/lách/hạch to
8,78% BN có biểu hiện thâm nhiễm thần kinh trung ương. AML thể M4 và M2 chiếm tỷ lệ cao nhất, lần lượt là 41,9% và 35,8%. CD33, MPO, CD13 là các dấu ấn dương tính chiếm tỷ lệ cao, lần lượt là 95,9%
78,4% và 51,4%. 47,3% BN có bất thường nhiễm sắc thể (NST), phổ biến nhất là t(8
21) chiếm 33,3%. Gen lai AML-ETO chiếm 28,95%
đột biến FLT3-ITD gặp ở 14,17%. Kết luận: Lơ xê mi cấp dòng tủy trẻ em, nhóm BN ≥10 tuổi chiếm tỉ lệ cao (39,9%)
Tỉ lệ nam/nữ là 1,2/1
hầu hết có biểu hiện thiếu máu (93,9%)
8,78% BN có biểu hiện thâm nhiễm thần kinh trung ương. AML thể M4 và M2 chiếm tỷ lệ cao (41,9% và 35,8%), phần lớn BN có mật độ tế bào tủy tăng (68,2%). 47,3% BN có bất thường NST. Bất thường phổ biến nhất là t(8
21), -Y, trisomy 8. Gen lai AMLETO và đột biến FLT3-ITD gặp với tỷ lệ cao (28,95% và 14,17%).

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