Nhân một trường hợp đa u tủy lớn tuổi mới chẩn đoán được điều trị bằng phác đồ có daratumumab=A case of newly diagnosed older multiple myeloma adjusted to treatment with daratumumab regimen

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Tác giả: Lê Cường Bùi, Dương Bích Trâm Huỳnh, Hồng Hoa Huỳnh, Thị Ngọc Hân Lê, Thị Thuý Tiên Nguyễn, Thanh Tùng Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.381-387

Bộ sưu tập: Báo, Tạp chí

ID: 478288

Thêm vào giỏ

Điều trị phác đồ có daratumumab cho bệnh nhân đa u tuỷ lớn tuổi mới chẩn đoán. Đối tượng và phương pháp: Báo cáo một trường hợp đa u tủy mới chẩn đoán được điều trị với phác đồ có daratumumab tại khoa Huyết Học bệnh viện Chợ Rẫy. Kết quả: Bệnh nhân nữ 85 tuổi với chẩn đoán đa u tủy xương được điều trị theo phác đồ DRd (daratumumab, lenalidomide và dexamethasone). Đánh giá sau 8 chu kì điều trị, bệnh nhân cải thiện về lâm sàng và đạt lui bệnh 1 phần (PR). Bệnh nhân được tiếp tục điều trị duy trì mỗi tháng với Daratumumab. Biến chứng ghi nhận trong quá trình điều trị gồm: lạnh run sau truyền Daratumumab liều đầu tiên, giảm bạch cầu hạt trong quá trình điều trị, thiếu máu, nhiễm trùng tiểu, huyết khối tĩnh mạch sâu chân phải. Các biến chứng này không yêu cầu phải ngưng liệu pháp điều trị đa u tủy. Kết luận: Ca bệnh này mô tả hiệu quả lâu dài của phác đồ có daramumumab trên bệnh nhân có thể trạng suy yếu và những tác dụng phụ có thể gặp trên bệnh nhân.Treatment regimen containing daratumumab for newly diagnosed older multiple myeloma patients. Subjects and Methods: Report of a newly diagnosed case of multiple myeloma treated with a regimen containing daratumumab at the Hematology Department at Cho Ray Hospital. Results: An 85-year-old female patient with a diagnosis of multiple myeloma was treated with the DRd regimen (daratumumab, lenalidomide and dexamethasone). Evaluation after 8 treatment cycles, the patient improved clinically and achieved partial remission (PR). Patients continued monthly maintenance treatment with Daratumumab. Complications recorded during treatment include: chills after the first dose of Daratumumab infusion, granulocytopenia during treatment, anemia, urinary tract infection, and right leg deep vein thrombosis. These complications do not require discontinuation of multiple myeloma therapy. Conclusion: This case describes the longterm effectiveness of a daramumumab-containing regimen in a patient with a weakened condition and the side effects that the patient may experience.

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