Đặc điểm kháng thể kháng tiểu cầu và các yếu tố liên quan đến giảm tiểu cầu miễn dịch dai dẳng của trẻ em tại bệnh viện Nhi Đồng 1=Characteristics of antiplatelet antibodies and the risk factors of persistent immune thrombocytopenia in children at Children's hospital 1

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Tác giả: Minh Tuấn Nguyễn, Ngọc Phương Uyên Vĩnh

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý:

Bộ sưu tập: Metadata

ID: 478295

Thêm vào giỏ

Describe the characteristics of antiplatelet antibodies in children with ITP at Children's Hospital 1. Explore some relationship between clinical and subclinical characteristics of progressing persistent ITP in children at Children’s Hospital 1. Research methodology: Prospective longitudinal study. Subjects: 124 newly diagnosed ITP patients admitted to Department of Dengue Hemorrhagic Fever and Hematology – Children’s hospital 1 from January 2024 to July 2024. Results: The prevalence of positive antiplatelet antibodies was 40% (n=73). Among these, isolated IgM was the most common isotype (52%), followed by the presence of all three isotypes (24%). Isolated IgA or IgG or the combination of IgA and IgM was observed in 7%, while 3% had both IgM and IgG. There was a positive relationship (p<
0.05) between the presence of IgG or IgA and the severity of bleeding. After 3 months of follow-up, the rate of persistent ITP was 32% (n=96). Factors associated with persistent ITP included platelet counts at 72 hours, 1 week, 2 weeks, 3 weeks, and 4 weeks post-treatment, as well as the initial treatment modality. Conclusion: The prevalence of antiplatelet antibodies was 40%, with IgM being the most frequently detected isotype. The rate of persistent ITP was 32%. A statistically significant association was found between the presence of IgG or IgA antiplatelet antibodies and bleeding severity. Factors associated with persistent ITP included platelet counts at various time points post-treatment and the initial treatment approach.Mô tả đặc điểm kháng thể kháng tiểu cầu của trẻ mắc GTCMD tại Bệnh viện Nhi Đồng 1 (BVNĐ1). (2) Khảo sát các yếu tố liên quan đến diễn tiến dai dẳng ở trẻ mắc GTCMD. Phương pháp nghiên cứu: Nghiên cứu tiến cứu theo dõi dọc Đối tượng: 124 bệnh nhi GTCMD mới chẩn đoán nhập viện tại khoa Sốt xuất huyết – Huyết học BVNĐ1, từ tháng 1/2024 đến tháng 7/2024. Kết quả: Tỷ lệ kháng thể kháng tiểu cầu (KTKTC) dương tính là 40% (n=73). Trong số đó, hiện diện đơn thuần isotype IgM là chủ yếu (52%), tiếp đến là hiện diện cả 3 isotype với 24%, 7% chỉ có IgA hoặc IgG hoặc IgA và IgM, 3% có IgM và IgG. Có mối liên quan có ý nghĩa thống kê (p<
0,05) giữa có kháng thể kháng tiểu cầu loại IgG hay IgA và mức độ xuất huyết. Sau 3 tháng theo dõi, tỷ lệ bệnh diễn tiến dai dẳng là 32% (n=96). Các yếu tố liên quan đến diễn tiến dai dẳng bao gồm: số lượng tiểu cầu tại các thời điểm 72 giờ, 1 tuần, 2 tuần, 3 tuần, 4 tuần sau điều trị
phương pháp điều trị lúc nhập viện. Kết luận: Tỷ lệ KTKTC dương tính là 40%, chủ yếu là isotype IgM. Tỷ lệ GTCMD dai dẳng là 32%. Có mối liên quan có ý nghĩa thống kê giữa sự hiện diện của kháng thể kháng tiểu cầu IgG hoặc IgA và mức độ xuất huyết. Các yếu tố liên quan đến diễn tiến bệnh dai dẳng bao gồm số lượng tiểu cầu tại các thời điểm 72 giờ, 1 tuần, 2 tuần, 3 tuần, 4 tuần sau điều trị và phương pháp điều trị ban đầu.

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1. Đọc trực tuyến

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