Khảo sát giá trị của biểu đồ phân tích hoạt tính peroxidase và mật độ nhân (PANDA) trong chẩn đoán bạch cầu cấp tại bệnh viện Chợ Rẫy=Survey of peroxidase activity and nuclear density analysis (PANDA) scattergram in the diagnosis of acute leukemia at Cho Ray hospital

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Tác giả: Thị Trang Cao, Văn Được Lê, La Thủy Tiên Nguyễn, Thị Bích Trâm Nguyễn, Thị Thảo Nguyễn, Ngọc Diễm Phạm, Châu Tài Quách, Thanh Tùng Trần, Thị Ánh Tuyến Trần, Ngọc Quyên Trương

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.425-434

Bộ sưu tập: Metadata

ID: 478296

Thêm vào giỏ

Patients diagnosed with acute leukemia at Cho Ray Hospital from June 2023 to June 2024. Research method: retrospective, descriptive cross-sectional. Results: We recorded 184 patients with acute myeloid leukemia (AML) and 42 patients with acute lymphoblastic leukemia (ALL) who met the selection criteria, in addition, 44 patients with chronic lymphoproliferative disease (CLPD) were also analyzed. The results showed that 98.5% of cases were classified in accordance with Onofrio's PANDA classification system. In the D1 – P0 pattern, the LUC ratio was statistically significantly different between the AML-M5, AML-M0 and ALL groups. The D1 – P1/P2/P3/P4 pattern helped to guide the diagnosis of AML and exclude ALL. The D1- P6 pattern helped to diagnose AML-M3 with a sensitivity and specificity of 88% and 91.7% respectively. Conclusion: the PANDA scattergram on the automated hematology analyzer has high value in guiding the diagnosis and classification of acute leukemia in many cases. The advantages of this method are its speed and convenience, which can help clinicians make a quick diagnosis and provide appropriate treatment for patients.Việc chẩn đoán sớm và xử trí ban đầu phù hợp là rất quan trọng đối với các bệnh nhân bạch cầu cấp. Khảo sát hình thái kết hợp hóa tế bào là phương pháp đầu tay quan trọng giúp chẩn đoán và phân loại bạch cầu cấp. Phương pháp phân tích hoạt tính peroxidase và mật độ nhân trên máy huyết học tự động có thể giúp phát hiện và đánh giá đặc điểm của tế bào non ở máu ngoại vi một cách nhanh chóng, hạn chế được nhiều nhược điểm của phương pháp thủ công. Đối tượng: Bệnh nhân (BN) được chẩn đoán bạch cầu cấp tại bệnh viện Chợ Rẫy từ tháng 6 năm 2023 đến tháng 6 năm 2024. Phương pháp nghiên cứu: hồi cứu, mô tả cắt ngang. Kết quả: Chúng tôi ghi nhận 184 BN bạch cầu cấp dòng tủy (AML) và 42 BN bạch cầu cấp dòng lympho (ALL) thỏa tiêu chuẩn chọn mẫu, bên cạnh đó 44 BN bệnh lý tăng sinh lympho mạn tính (CLPD) cũng được phân tích. Kết quả cho thấy 98,5% trường hợp có phân loại phù hợp với hệ thống phân loại PANDA của Onofrio. Ở nhóm biểu đồ D1 – P0, tỉ lệ LUC khác biệt có ý nghĩa thống kê giữa nhóm AML-M5, AML-M0 và ALL. Dạng biểu đồ D1 – P1/P2/P3/P4 giúp định hướng chẩn đoán AML và loại trừ ALL. Dạng biểu đồ D1- P6 giúp chẩn đoán AML-M3 với độ nhạy và độ đặc hiệu lần lượt là 88% và 91,7%. Kết luận: Biểu đồ PANDA trên máy phân tích huyết học tự động có giá trị cao giúp định hướng chẩn đoán và bước đầu phân loại bệnh bạch cầu cấp. Ưu điểm của phương pháp này là sự nhanh chóng, tiện lợi, có thể giúp bác sĩ lâm sàng chẩn đoán nhanh và xử trí ban đầu phù hợp .

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