Báo cáo trường hợp người bệnh u lympho tế bào T ở trẻ em có nhiễm Epstein-Barr virus=Systemic Epstein-Barr virus positive T-cell lymphoma of the childhood: A case report

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Tác giả: Hoàng Thiên Đặng, Nghĩa Huỳnh, Ngô Quang Thạch Phan, Vanessa Dayton

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.501-507

Bộ sưu tập: Metadata

ID: 478316

Thêm vào giỏ

S-EBV-TCL is a rapidly progressive disease, infiltrating many organs, leading to multiple end-organ dysfunction syndrome, and can be fatal. Purpose: Reporting a S-EBV-TCL patient being diagnosed and treated at Blood Transfusion Hospital. Materials and method: A case report. The diagnosis was based on the pathology examination of the lymph node, and PET-CT scan was used for staging and response assessment. Results: After two cycles of SMILE regimen, the patient were refractory to the protocol. She was then treated with ICE regimen, and she achieved partial response, with significant recessive of the size and the FDG uptake of the neoplastic sites of multiple organs. Conclusions: S-EBV-TCL is a rare disease, which is associated with the complex scenarios of EBV infection. There is no standard treatment protocol.U lympho tế bào T ở trẻ em có nhiễm Epstein-Barr virus (Systemic EBV positive T-cell lymphoma of childhood – S-EBVTCL) là một bệnh lí tiến triển nhanh, xâm lấn nhiều hệ cơ quan, gây suy đa cơ quan, và có thể tử vong. Mục tiêu nghiên cứu: Báo cáo một trường hợp người bệnh S-EBV-TCL được chẩn đoán, và điều trị tại bệnh viện Truyền máu Huyết học. Đối tượng và phương pháp nghiên cứu: Báo cáo ca. Chúng tôi chẩn đoán cho người bệnh dựa trên kết quả giải phẫu bệnh từ mẫu sinh thiết hạch, đánh giá giai đoạn bệnh và đáp ứng điều trị dựa trên PET-CT scan. Kết quả nghiên cứu: Sau hai chu kì hoá trị liệu với phác đồ SMILE, người bệnh được đánh giá kháng trị. Chúng tôi chuyển đổi sang phác đồ ICE, và sau hai chu kì, người bệnh đạt lui bệnh một phần, giảm đáng kể kích thước và tín hiệu hấp thu FDG của các tổn thương ác tính xâm lấn đa cơ quan. Kết luận: S-EBV-TCL là một bệnh lí hiếm gặp, nằm trong bối cảnh phức tạp của nhiễm EBV. Phác đồ điều trị hiện chưa được chuẩn hoá.

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