Nghiên cứu các chỉ số NLR, PLR và PNR trong đánh giá tình trạng viêm ở bệnh nhân lupus ban đỏ hệ thống=Research of NLR, PLR and PNR indicators in assessing inflammatory status in patients with systemic lupus erythematosus

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Nữ Thùy Dương Hà, Trần Phương Hồ, Thị Anh Thư Hoàng, Phan Minh Triết Lê, Đắc Duy Nghiêm Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.508-516

Bộ sưu tập: Metadata

ID: 478317

Thêm vào giỏ

Lupus ban đỏ hệ thống (LBĐHT) là bệnh lý tự miễn gây viêm hệ thống mạn tính và ảnh hưởng đến chức năng của nhiều cơ quan, hậu quả của rối loạn dung thứ miễn dịch trong đáp ứng của cơ thể với chính kháng nguyên bản thân. Trong LBĐHT, tỷ lệ bạch cầu hạt trung tính/bạch cầu lympho (NLR) và tỷ lệ giữa tiểu cầu/bạch cầu lympho (PLR) thường cao hơn, trong khi đó tỷ lệ tiểu cầu/bạch cầu hạt trung tính (PNR) thấp hơn người bình thường, những chỉ số này có liên quan đáng kể đến mức độ tiến triển của bệnh và là chỉ số sinh học giúp theo dõi hoạt động của bệnh. Vì vậy nghiên cứu được thực hiện nhằm mục đích tìm hiểu sự thay đổi một số chỉ số huyết học ở bệnh nhân lupus ban đỏ hệ thống. Đối tượng và phương pháp nghiên cứu: Nghiên cứu được tiến hành trên 82 bệnh nhân LBĐHT mới được chẩn đoán tại Khoa Nội tổng hợp – Nội tiết – Cơ xương khớp và nhóm chứng gồm 95 người khỏe mạnh đến khám sức khỏe tại bệnh viện Trường Đại học Y Dược Huế từ tháng 06/2022 đến tháng 03/2024. Kết quả: Chỉ số NLR, PLR ở bệnh nhân LBĐHT cao hơn, trong khi đó PNR thấp hơn có ý nghĩa thống kê so với nhóm chứng (p <
0,05). Dựa trên đường cong ROC, điểm cắt tốt nhất của NLR, PLR và PNR trong dự báo bệnh LBĐHT là 1,7, 111,9 và 68,9. Chỉ số NLR tương quan thuận mức độ mạnh với PLR (r = 0,619, p <
0,001) và số lượng bạch cầu chung (r = 0,521, p <
0,001), PNR tương quan nghịch mức độ mạnh với NLR (r = -0,512, p <
0,001) và số lượng bạch cầu chung (r = -0,663, p <
0,001).Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease and has various clinical manifestations affecting organ systems, consequences of immune tolerance disorders in the body's response to self -antigens. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in SLE are often higher, however platelet-to-neutrophil ratio (PNR) is lower than in the normal population, which is significantly related to disease progression and is an indicator of monitoring disease activity. Therefore, the study was conducted with the aim of understanding the change of some hematological indexes in patients with SLE. Materials and method: The study was conducted on 82 patients with newly diagnosed SLE at the Department of General Internal Medicine - Endocrinology - Musculoskeletal and a control group of 95 healthy people who came to the hospital of Hue University of Medicine and Pharmacy from June 2022 to March 2024. Results: NLR and PLR indexes in patients with SLE were higher and PNR was lower with statistical significance compared to the control group (p <
0.05). Based on the ROC curve, the best cutoff points of NLR, PLR and PNR in predicting SLE are 1.7, 111.9 and 68.9. NLR index strongly positively correlated with PLR (r = 0.619, p <
0.001) and white blood cell count (r = 0.521, p <
0.001), PNR strongly negatively correlated with NLR (r = -0.512 , p <
0.001) and white blood cell count (r = -0.663, p <
0.001).

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