Mức độ kháng kháng sinh của một số chủng vi khuẩn gây nhiễm khuẩn huyết ở bệnh nhi lơ xê mi cấp tại Viện Huyết học - Truyền máu Trung ương giai đoạn 2021 – 2023=Antibiotic resistance of bacterial strains causing sepsis in pediatric acute leukemia patients at the National Institute of Hematology and Blood Transfusion from 2021 to 2023

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Tác giả: Thị Hưng Dương, Thu Hằng Dương, Thị Hồng Hoàng, Khánh Quỳnh Lê, Thị Nguyệt Lê, Lan Mai, Thị Hương Giang Nguyễn, Quỳnh Mai Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.524-531

Bộ sưu tập: Metadata

ID: 478319

Thêm vào giỏ

Phân tích mô hình và mức độ kháng kháng sinh của một số chủng vi khuẩn gây nhiễm khuẩn huyết ở bệnh nhi lơ xê mi cấp tại Viện Huyết học – Truyền máu Trung ương giai đoạn 2021 – 2023. Đối tượng và phương pháp nghiên cứu: nghiên cứu hồi cứu, mô tả cắt ngang trên 399 chủng vi khuẩn được phân lập từ bệnh phẩm cấy máu của 375 bệnh nhi lơ xê mi cấp điều trị tại khoa Bệnh máu trẻ em, Viện Huyết học – Truyền máu Trung ương giai đoạn 2021 – 2023. Kết quả: Trong 399 chủng vi khuẩn được nghiên cứu, vi khuẩn gram âm chiếm tỷ lệ cao nhất 73,7%. Các vi khuẩn gây nhiễm khuẩn huyết thường gặp nhất theo thứ tự lần lượt là P.aeruginosa, E.coli, K.pneumoniae và S.aureus. Các chủng P.aeruginosa còn khá nhạy cảm với các kháng sinh thông dụng, E.coli còn khá nhạy cảm với Amikacin và các Carbapenem, K.pneumoniae kháng với hầu hết các loại kháng sinh với tỷ lệ cao. Không có chủng vi khuẩn nào kháng Colistin.Trong các chủng S.aureus phân lập được, tỷ lệ MRSA chiếm 73,3%. Không có chủng MRSA và MSSA nào kháng Vancomycin. Kết luận: Kết quả nghiên cứu cung cấp cơ sở cho các bác sĩ lâm sàng về việc sử dụng kháng sinh theo kinh nghiệm cho các bệnh nhi lơ xê mi cấp được chẩn đoán nhiễm khuẩn huyết khi chưa có kháng sinh đồ.The study aims to analysis the pattern and antibiotic resistance levels of bacteria causing sepsis in pediatric acute leukemia patients at the National Institute of Hematology and Blood Transfusion from 2021 to 2023. Subjects and Methods: A retrospective, cross-sectional study was conducted on 399 bacterial strains isolated from blood cultures of 375 pediatric acute leukemia patients treated at the Pediatric Hematology Department of the National Institute of Hematology and Blood Transfusion during the 2021–2023 period. Results: Among the 399 bacterial strains studied, gram-negative bacteria accounted for the highest proportion at 73.7%. The most common bacteria causing sepsis, in order, were P.aeruginosa, E.coli, K.pneumoniae, and S.aureus. P.aeruginosa strains remained relatively sensitive to commonly used antibiotics, while E.coli was still quite sensitive to Amikacin and Carbapenems. K.pneumoniae showed high resistance to most antibiotics. No bacterial strain was resistant to Colistin. Among the isolated S.aureus strains, 73.3% were Methicillinresistant S.aureus (MRSA). No MRSA or Methicillin-sensitive S.aureus (MSSA) strains were resistant to Vancomycin. Conclusion: The study results provide a basis for clinicians to make empirical antibiotic treatment decisions for pediatric acute leukemia patients diagnosed with sepsis when antibiotic susceptibility results are not yet available.

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