Nghiên cứu các yếu tố liên quan đến kháng thể kháng nhân (ANA) dương tính ở bệnh nhân tại bệnh viện E=Research on factors associated with positive antinuclear antibodies (ANA) in patients at E hospital

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Tác giả: Bảo Châu Đặng, Thị Vân Hà Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.581-589

Bộ sưu tập: Metadata

ID: 478327

Thêm vào giỏ

Antinuclear antibodies (ANA) status assessment and related factors in positive ANA patient in E hospital. Subjects: 110 patients were tested for antinuclear antibodies (ANA 23 profile) at the Department of Hematology, E Hospital. Research methods: Cross-sectional description, T-test, Chi-q test. Results: 110 patients including 56 patients with clinical classified symptoms, recommended for autoimmune diseases screening and 54 patients with atypical clinical symptoms
74 (67.3%) patients were positive for at least one of 23 antinuclear autoantibodies (ANA) and 36 (32.7%) patients tested negative. The study also showed the effect of gender on the positive ANA rate (women had a higher rate than men) with p = 0.026 but the difference was between three age groups 0 -20
21 – 50
51 – 90 years old is not statistically significant. The study found that although there is a statistical correlation between the positive ANA rate and research group with classified clinical symptoms, the ANA results in the overall screening study may be affected by the patient's underlying symptoms and also by gender and age.Khảo sát các yếu tố liên quan đến một kết quả kháng thể kháng nhân (ANA) dương tính trên các bệnh nhân tại bệnh viện E. Đối tượng: 110 bệnh nhân được thực hiện xét nghiệm kháng thể kháng nhân (ANA 23 profile) tại Khoa Huyết học, Bệnh viện E. Phương pháp nghiên cứu: Mô tả cắt ngang, Thống kê T-test, Chi-q test. Kết quả: Nhóm nghiên cứu 110 bệnh nhân bao gồm 56 bệnh nhân với triệu chứng lâm sàng đã được phân loại, khuyến cáo cho các bệnh tự miễn và 54 bệnh nhân có triệu chứng lâm sàng không điển hình rõ ràng
74 (67,3%) bệnh nhân dương tính với ít nhất một trong 23 tự kháng thể kháng nhân (ANA) và 36 (32,7%) bệnh nhân cho kết quả âm tính. Nghiên cứu cũng cho thấy ảnh hưởng của giới tính tới tỷ lệ ANA dương tính (nữ có tỷ lệ cao hơn nam) với p = 0,026 nhưng sự khác biệt giữa ba nhóm tuổi 0 – 20
21 – 50
51 – 90 tuổi không có ý nghĩa thống kê. Nghiên cứu cho thấy mặc dù có mối tương quan giữa tỷ lệ ANA dương tính và nhóm có triệu chứng lâm sàng điển hình nhưng kết quả ANA trên tổng thể nghiên cứu sàng lọc có thể bị ảnh hưởng bởi các triệu chứng lâm sàng không điển hình và còn bị ảnh hưởng bởi giới tính cũng như độ tuổi.

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