Nghiên cứu đặc điểm kết quả huyết tuỷ đồ trên một số bệnh máu ác tính tại bệnh viện Đà Nẵng=Study on characteristics of blood smear and bone marrow aspiration in hematological malignancies in Danang hospital

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Hà Thanh Nhã Nguyễn, Nhã Vi Nguyễn, Thị Ngọc Ánh Phạm, Thị Thanh Hương Trần, Thế Diễm Trinh Trương

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 2024

Mô tả vật lý: tr.639-645

Bộ sưu tập: Metadata

ID: 478340

Thêm vào giỏ

Mô tả đặc điểm xét nghiệm huyết tuỷ đồ
đánh giá sự phù hợp giữa kết quả tuỷ đồ và các xét nghiệm khác (kiểu hình miễn dịch và sinh thiết tuỷ xương) của một số bệnh được chẩn đoán xác định bệnh máu ác tính mới theo tiêu chuẩn phân loại của Tổ chức y tế thể giới về u hệ tạo máu và cơ quan lympho (WHO 2016) tại Bệnh viện Đà Nẵng. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang các trường hợp được chẩn đoán mới bệnh máu ác tính tại bệnh viện (BV) Đà Nẵng từ 01/01/2022 đến 30/6/2023. Kết quả: Nghiên cứu trên 209 bệnh nhân (BN) (>
15 tuổi) được làm xét nghiệm huyết tuỷ đồ và được chẩn đoán xác định bệnh máu ác tính mới theo tiêu chuẩn phân loại của WHO 2016: nhóm bệnh lơ xê mi cấp dòng tuỷ (AML) chiếm tỷ lệ cao nhất (28,2%), ít gặp nhất là nhóm bệnh lơ xê mi cấp dòng lympho (ALL) (5,3%). Số lượng bạch cầu (WBC) phần lớn đều tăng >
40G/L
số lượng tiểu cầu (PLT) tăng rõ rệt trong nhóm bệnh tăng sinh tuỷ ác tính (MPN)
hầu hết bệnh nhân đều có Hemoglobin (Hb)<
120g/l, trừ nhóm bệnh MPN. Mật độ tế bào (MĐTB) tuỷ phần lớn là giàu tế bào, gặp trong nhóm bệnh lơ xê mi cấp (AL), tăng sinh lympho ác tính (LPD), MPN. Có 69 bệnh nhân thực hiện đồng thời tuỷ đồ, kiểu hình miễn dịch, trong đó 10 trường hợp không có sự tương đồng kết quả giữa 2 phương pháp chủ yếu gặp nhóm bệnh AL. Có 18 bệnh nhân thực hiện sinh thiết tuỷ xương (STTX) đều có kết quả phù hợp. Kết luận: Xét nghiệm huyết tuỷ đồ giúp định hướng và chẩn đoán xác định phần lớn bệnh máu ác tính. Tuy nhiên, hiện nay việc kết hợp các xét nghiệm chuyên sâu khác (kiểu hình miễn dịch, STTX, sinh học phân tử) là rất cần thiết.To describe the characteristics of blood smear and bone marrow aspiration and evaluate the suitability among the results of blood smear, bone marrow aspiration, and other analyses (immunophenotype, bone marrow biopsy, molecular biology) in new hematological malignancy diagnostic according to The World Health Organization classification of tumors of the hematopoietic and lymphoid tissues (WHO 2016) in Da Nang Hospital. Subjects and research methods: Crosssectional study of new hematological malignancy diagnostic cases in Da Nang Hospital from 01/01/2022 to 30/6/2023. Result: 209 cases (>
15 years old) were done blood smear - and bone marrow aspiration tests for the first time, and were new hematological malignancy diagnostic according to WHO 2016 standard: acute myeloid leukemia was the highest proportion (28,2%), the lowest one was acute lymphoid leukemia (5,3%). White blood cell counts were mostly >
40G/L
platelet counts significantly were high in myeloproliferative neoplasm (MPN)
most patients had hemoglobin <
120g/l except for MPN. Cellularity were mainly hypercellular in acute leukemia (AL), lymphoproliferative disorders and MPN. There were 69 cases of bone marrow aspiration and immunophenotype simultaneously, in which 10 cases were different in results, frequently in AL cases. Bone marrow biopsy was performed in 18 cases, and the results were suitable. Conclusion: Blood smear and bone marrow aspiration help to orientate and diagnose hematological malignancy. However, combining other specific tests (immunophenotype, bone marrow biopsy, molecular biology) is extremely essential.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR