Bước đầu nhận xét đặc điểm mô khí quản đồng loài được bảo quản lạnh sâu tại Ngân hàng Mô, Bệnh viện Hữu nghị Việt Đức=An initial observation on the characteristics of cryopreserved tracheal allografts tissues at the Tissue Bank of Viet Duc University Hospital

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Tác giả: Thị Hằng Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Khoa học và Công nghệ Việt Nam, 2025

Mô tả vật lý: tr.63-69

Bộ sưu tập: Metadata

ID: 478466

Thêm vào giỏ

Các dữ liệu về bảo quản khí quản và kết quả đánh giá sau bảo quản vẫn còn hạn chế trong y văn hiện nay tại Việt Nam. Nghiên cứu này nhằm mô tả đặc điểm khí quản được bảo quản lạnh sâu tại Ngân hàng Mô. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả, tiến cứu trên 13 mẫu mô khí quản từ người hiến chết não được bảo quản tại Ngân hàng Mô, Bệnh viện Hữu nghị Việt Đức. Kết quả nghiên cứu cho thấy, 13 mẫu khí quản được thu nhận từ 13 người hiến chết não, độ tuổi trung bình 35,2±15,2, gồm 9 nam (69,2%) và 4 nữ (30,8%). Xét nghiệm huyết thanh học âm tính với HIV 13/13 (100%), HCV 13/13 (100%), HBV 12/13 (92,4%). Trong giai đoạn thu nhận, mô khí quản có tỷ lệ nhiễm khuẩn là 100% (13/13 mẫu). Sau khử nhiễm, tỷ lệ cấy khuẩn âm tính là 69,2% (9/13 mẫu). Vi khuẩn phổ biến nhất là Acinetobacter baumannii (8/18 chủng) và Klebsiella pneumoniae (6/18 chủng). 13/13 (100%) mẫu khí quản giữ được cấu trúc đại thể và cấu trúc vi thể sau rã đông trong thời gian bảo quản từ 1 đến 12 tháng. Mô khí quản sau bảo quản lạnh sâu đã được ghép thành công cho một bệnh nhân bị sẹo hẹp thanh khí quản do chấn thương, cho kết quả khả quan sau 1-3 tháng.Data on tracheal preservation and post-preservation evaluation remain limited in the current medical literature in Vietnam. This study aims to describe the characteristics of tracheal tissues stored under in deep cryopreservation conditions at the Tissue Bank. Subjects and methods: Descriptive, prospective study on 13 tracheal tissue samples from brain-dead donors preserved at the Tissue Bank of Viet Duc Hospital. Results showed that 13 tracheal samples were collected from 13 brain-dead donors, with an average age of 35.2±15.2, including 9 males (69.2%) and 4 females (30.8%). Serological tests were negative for HIV 13/13 (100%), HCV 13/13 (100%), and HBV 12/13 (92.4%). During the recovery phase, the infection rate of tracheal tissue was 13/13 (100%). After decontamination, the negative culture rate was 9/13 (69.2%). The most common bacteria were Acinetobacter baumannii (8/18 strains) and Klebsiella pneumoniae (6/18 strains). 13/13 (100%) tracheal specimens retained their gross and microscopic structures after thawing for a storage period of 1-12 months. The cryopreserved tracheal tissue was successfully transplanted into a patient with post-traumatic laryngotracheal stenosis, showing positive outcomes within 1-3 months posttransplantation.

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