Khảo sát hoạt tính chống stress oxy hóa in vitro từ cao chiết lá cây thạch vĩ (Pyrrosia lingua (Thunb.) Farwell)

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thế Vinh Bùi, Phan Phương Nhi Nguyễn, Thị Lên Nguyễn, Thị Thu Hương Nguyễn, Đức Vũ Phạm, Ngọc Khôi Phạm, Sĩ Nguyên Trần, Tiến Tài Trần, Đức Trí Dũng Võ, Tấn Khang Võ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2024

Mô tả vật lý: tr.82

Bộ sưu tập: Báo, Tạp chí

ID: 479412

Thêm vào giỏ

Stress oxy hóa là sự mất cân bằng giữa các gốc tự do và chất chống oxy hóa trong cơ thể. Điều này có thể gây tổn thương cho các mô, cơ quan và dẫn đến nhiều bệnh khác nhau. Trong bối cảnh Việt Nam chưa có nhiều nghiên cứu về hoạt tính sinh học của lá cây thạch vĩ (Pyrrosia lingua (Thunb.) Farwell), nghiên cứu này được thực hiện nhằm khảo sát hoạt tính chống stress oxy hóa in vitro của cao chiết ethanol 70% từ lá cây thạch vĩ. Cao chiết từ lá cây thạch vĩ có khả năng kháng oxy hóa cao (IC50 = 157,09 µg/ml cho thử nghiệm dập tắt gốc tự do DPPH, IC50 = 23,12 µg/ml cho thử nghiệm ức chế peroxy hóa lipid tế bào, IC50 = 141,03 µg/ml cho thử nghiệm ức chế xanthine oxidase in vitro), nhưng vẫn thấp hơn so với mẫu đối chứng lần lượt là Acid ascorbic (IC50 = 4,97 µg/ml), Trolox (IC50 = 27,88 µg/ml), Allopurinol (IC50 = 3,77 µg/ml). Nghiên cứu này đã khảo sát được hoạt tính chống stress oxy hóa in vitro của cao chiết ethanol 70% từ lá cây thạch vĩ. Điều này giúp bổ sung tiềm năng hỗ trợ điều trị bệnh từ lá cây thạch vĩ, từ đó làm cơ sở cho các nghiên cứu sâu hơn về hoạt tính sinh học khác của lá cây thạch vĩ. Abstract Oxidative stress is an imbalance between free radicals and antioxidants in human body. This can cause damage to tissues, organs and result in various diseases. In Vietnam, there are not many studies on the leaves of tongue fern (Pyrrosia lingua (Thunb.) Farwell), the aim of this study was carried out to investigate in vitro anti-oxidative stress activities from 70% ethanol extract of tongue fern. The extract from the leaves of tongue fern has high antioxidant capacity (IC50 = 157.09 µg/ml for capturing free radicals DPPH, IC50 = 23.12 µg/ml for inhibition of cellular lipid peroxidation, IC50 = 141.03 µg/ml for xanthine oxidase inhibition in vitro test), but still lower than the control sample such as Ascorbic acid (IC50 = 4.97 µg/ml), Trolox (IC50 = 27.88 µg/ml), Allopurinol (IC50 = 3.77 µg/ml), respectively. This study has investigated in vitro anti-oxidative stress activities from 70% ethanol extract of tongue fern. This helps add to the potential to support disease treatment from tongue fern, thereby serving as a basis for further research on other biological activities of tongue fern. DOI: 10.59715/pntjmp.3.3.9

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR