ANTI-LIPASE AND MCF-7 BREAST CANCER CELL PROLIFERATION INHIBITION IN VITRO OF THE EXTRACT-ENRICHED POLYPHENOLS AND SAPONINS FROM Musa balbisiana FRUIT=ANTI-LIPASE AND MCF-7 BREAST CANCER CELL PROLIFERATION INHIBITION IN VITRO OF THE EXTRACT-ENRICHED POLYPHENOLS AND SAPONINS FROM Musa balbisiana FRUIT

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Tác giả: Dinh Khanh Dieu, Thi Ngoc Nhon Hoang, Huynh Tram Nguyen, Thi Thu Huyen Nguyen

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học Đại học Công Thương (Tên cũ: Tạp chí Khoa học Công nghệ và Thực phẩm), 2024

Mô tả vật lý: tr.93

Bộ sưu tập: Báo, Tạp chí

ID: 479861

Thêm vào giỏ

Chuối hột Musa balbisiana là một trong những loại chuối phổ biến trên thế giới và các bộ phận của nó đã được sử dụng rộng rãi trong y học. Nghiên cứu này nhằm xác định khả năng ức chế enzyme lipase và ức chế sự tăng sinh dòng tế bào ung thư vú MCF-7 của chiết xuất giàu polyphenol và saponin từ quả chuối hột M. balbisiana. Hoạt tính kháng lipase cao của dịch chiết được đánh giá thông qua xét nghiệm lipase tụy và hoạt tính chống tăng sinh dòng tế bào ung thư vú MCF-7 bằng xét nghiệm SRB. Kết quả cho thấy dịch chiết thu được có khả năng ức chế lipase và ức chế tăng sinh dòng tế bào MCF-7 với giá trị IC50 lần lượt là 48,82 ± 1,21 μg/mL và 289,5 ± 8,7 μg/mL. Điều này cho thấy chiết xuất thu được từ quả chuối hột có thể có tiềm năng được sử dụng như một tác nhân hỗ trợ giảm béo phì và ức chế sự phát triển của dòng tế bào ung thư vú.Musa balbisiana is one of the most widely used bananas, and its parts have been used in medicine worldwide. This study aimed to determine the anti-lipase and the inhibition of MCF-7 breast cancer cells proliferation of the polyphenol and saponin-enriched extract from M. balbisiana fruit. The potent anti-lipase activity of the extract was observed via an assay for pancreatic lipase, and the anticancer activity of the extract was assessed through its anti-proliferative ability on MCF-7 breast cancer cells by sulforhodamine B assay. This study concluded that the extract had high lipase and MCF-7 cell inhibition with IC50 values of 48.82 ± 1.21 μg/mL and 289.5 ± 8.7 μg/mL, respectively. These results suggest that the obtained extract from M. balbisiana fruit might have the potential to be used as an agent to support obesity reduction and inhibit breast cancer cell proliferation.

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