SO SÁNH HOẠT TÍNH ỨC CHẾ ENZYME ALPHA-AMYLASE VÀ BẮT GỐC TỰ DO DPPH CỦA MỘT SỐ DƯỢC LIỆU=COMPARISON OF ALPHA-AMYLASE ENZYME INHIBITION AND DPPH FREE RADICAL SCAVENGING ACTIVITIES OF SOME MEDICINAL PLANTS

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Tác giả: Ngô Đại Hùng, Khánh Trần Minh, Sang Võ Thanh

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học - Đại học Thủ Dầu Một, 2024

Mô tả vật lý: tr.47-51

Bộ sưu tập: Metadata

ID: 480371

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Numerous medicinal plants in Vietnam have been used as a remedy for the prevention and treatment of diabetes. In this study, the inhibitory activity of the α-amylase enzyme and the free radical scavenging capacity of some medicinal herbs such as Psidium guajava leaves, Mangifera indica leaves, Physalis angulata, Pandanus amaryllifolia leaves, Ficus glomerata leaves, Artocarpus altilis leaves, and Gomphrena celosioides were compared to identify suitable medicinal sources for application in the treatment of type 2 diabetes. The results showed that the ethanol extracts of the above medicinal herbs exhibited α-amylase inhibitory activity with IC50 values of 136.8
184.7
228.3
159.1
264.5
152.4
and 204.4µg/ml, respectively. Furthermore, it was determined that the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity of these medicinal herbs at a concentration of 100 µg/ml was 58.5%
47.8%
38.6%
38.2%
39.4%
51.1%
and 33.7%, respectively. Thus, the Psidium guajava leaf extract showed the highest α-amylase inhibitory activity and DPPH free radical scavenging activity, providing a basis for the application of guava leaves in the prevention and treatment of type 2 diabetes.Việt Nam có nhiều nguồn dược liệu có thể được sử dụng trong phòng ngừa và hỗ trợ điều trị bệnh đái tháo đường. Trong nghiên cứu này, hoạt tính ức chế enzyme thủy phân tinh bột α-amylase và khả năng bắt gốc tự do của một số dược liệu như lá ổi (Psidium guajava), lá xoài (Mangifera indica), tầm bóp (Physalis angulata), lá dứa (Pandanus amaryllifolia), lá sung (Ficus glomerata), lá sake (Artocarpus altilis), và bạc đầu (Gomphrena celosioides) đã được so sánh để xác định nguồn dược liệu phù hợp cho việc ứng dụng trong hỗ trợ điều trị đái tháo đường loại 2. Kết quả khảo sát cho thấy rằng các cao chiết ethanol của các dược liệu trên có hoạt tính ức chế enzyme α-amylase tại giá trị IC50 lần lượt là 136,8
184,7
228,3
159,1
264,5
152,4
và 204,4µg/ml. Hơn nữa, hoạt tính bắt gốc tự do DPPH (2,2-diphenyl-1-picrylhydrazyl) của các dược liệu trên cũng được xác định tại nồng độ 100 µg/ml lần lượt là 58,5%
47,8%
38,6%
38,2%
39,4%
51,1%
và 33,7%. Như vây, cao chiết lá ổi có hoạt tính ức chế enzyme α-amylase và hoạt tính bắt gốc tự do DPPH cao nhất, tạo cơ sở cho việc ứng dụng lá ổi trong hỗ trợ phòng ngừa và chữa trị đái tháo đường loại 2.

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