Khảo sát điều kiện chiết xuất lá cây Dung (Symplocos cochinchinensis (Lour.) Moore) để thu cao chiết có hoạt tính chống oxy hóa=Investigation of extraction conditions for obtaining an potential antioxidant extract from the leaves of Symplocos cochinchinensis (Lour.) S. moore

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Tác giả: Quang Minh Chế, Bích Ngọc Giàu Lư, Thiện Vy Phan

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2024

Mô tả vật lý: tr.45

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ID: 480484

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"Dung" (Symplocos cochinchinensis) is a woody plant species commonly found in the Central and Tay Nguyen regions of Vietnam. The leaves of S. cochinchinensis are often used in traditional medicine to support the digestive system and treat indigestion and menstrual disorders. Several studies have demonstrated that leaf extract has many valuable activities, including lipid-lowering, antioxidant, cytotoxic, and hypoglycemic properties. The study collected and identified Dung leaf samples from Tra Bong district, Quang Ngai province, by using the DNA method. This research investigated the extraction conditions for obtaining the most effective antioxidant extract from S. cochinchinensis leaves. Serveral solvents were used for screening method, including water, ethanol (EtOH) 50 %, 70 % and 96 %. At the same time, supporting conditions such as ultrasound and temperature are also considered. The results showed that extraction with 70 % EtOH and ultrasound for 20 minutes at 40 oC produced the extract with the best antioxidant activity (IC50 = 439.99 ± 14.58 µg/mL). This extraction process can serve as a premise for developing products from Dung leaves.Cây Dung là một loài cây gỗ thường mọc ở miền Trung và Tây Nguyên. Lá Dung thường được sử dụng trong y học cổ truyền để hỗ trợ hệ tiêu hóa, chữa các chứng khó tiêu và rối loạn kinh nguyệt. Nhiều nghiên cứu đã chỉ ra rằng dịch chiết từ lá Dung có nhiều hoạt tính hữu ích, bao gồm khả năng hạ lipid máu, chống oxy hóa, gây độc tế bào và hạ đường huyết. Nghiên cứu đã thu thập và xác định được mẫu thực vật lá Dung từ huyện Trà Bồng, tỉnh Quảng Ngãi là loài Symplococ cochinchinenis bằng phương pháp DNA. Nghiên cứu tối ưu hóa hoạt tính chống oxy hóa của lá Dung, được thực hiện bằng phương pháp khảo sát điều kiện chiết xuất.Các dung môi được sử dụng bao gồm nước, ethanol (EtOH) (50, 70 và 96) %. Ngoài ra, các điều kiện hỗ trợ như siêu âm và nhiệt độ cũng được xem xét. Kết quả cho thấy rằng chiết xuất bằng EtOH 70 % và siêu âm trong 20 phút tại 40 oC tạo ra cao chiết có hoạt tính chống oxy hóa đánh giá bằng phương pháp bắt gốc tự do DPPH tốt nhất, C50 = (439,99 ± 14,58) µg/mL

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