Antiphospholipid syndrome is defined by two major components: the occurrence of at least one clinical feature from a diverse list of potential disease manifestations the most common of which are venous or arterial thromboses, recurrent fetal loss, thrombocytopenia and persistent presence in the serum of at least one of type of antiphospholipid antibody. The author reported clinical and instrumental findings in a young patient with end-stage renal failure, thrombose and antiphospholipid antibody.