In recent years, the management of professional development activities for teachers of Natural Sciences at Dang Cong Binh Secondary School, Hoc Mon District, Ho Chi Minh City has always been of interest and focus, but in reality, teachers of Natural Sciences still encounter many difficulties in the teaching process. Most Natural Sciences teachers have not been fully equipped with in-depth professional knowledge, integrated teaching capacity, and appropriate teaching methods and forms for Natural Sciences. This article briefly introduces the results of research on the management of professional development activities for teachers of Natural Sciences at Dang Cong Binh Secondary School, Hoc Mon District, Ho Chi Minh City.