LIGNANS FROM THE LEAVES OF SYMPLOCOS COCHINCHINESIS=CÁC HỢP CHẤT LIGNAN TỪ LÁ LOÀI SYMPLOCOS COCHINCHINESIS

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Tác giả: Thi Giang Le, Thi Anh Tuyet Nguyen, Xuan Nhiem Nguyen, Khac Ban Ninh

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2024

Mô tả vật lý: tr.344 - 349

Bộ sưu tập: Metadata

ID: 480572

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Symplocos cochinchinensis (Lour.) S. Moore is a medicinal herb belonging to the Symplocaceae family, widely distributed in tropical and subtropical regions of Asia, including China, Taiwan, India, Japan, and Malaysia. S. cochinchinensis is extensively used in many traditional folk remedies to treat conditions such as tumors, jaundice, diarrhea, dysentery, menstrual disorders, infections, diabetes, and uterine issues... In Vietnam, this species is used to treat burns, liver deficiency, stop bleeding, and sexually transmitted diseases. Recent studies have shown that this species possesses various activities such as anti-cancer, anti-inflammatory, antibacterial, hypoglycemic, and hepatoprotective effects. In this study, two lignans including matairesinol 4-O-β-D-glucopyranoside (1) and nortrachelogenin 4-O-β-D-gluopyranoside (2) were isolated from the methanol extract of S. cochinchinensis leaves using modern chromatographic techniques such as thin-layer chromatography, column chromatography, and high-performance liquid chromatography. The structures of the compounds were elucidated through analysis of high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1D-NMR spectra, 2D-NMR spectra, and comparison with spectral data from reference literature. Compounds 1 and 2 were isolated for the first time from the species S. cochinchinensis and from the genus Symplocos worldwide.Symplocos cochinchinensis (Lour.) S. Moore là một loại cây thảo dược thuộc họ Symplocaceae, phân bố rộng rãi ở các vùng nhiệt đới và cận nhiệt đới châu Á bao gồm Trung Quốc, Đài Loan, Ấn Độ, Nhật Bản, Malaysia. S. cochinchinensis được sử dụng rộng rãi trong nhiều bài thuốc dân gian điều trị các bệnh khối u, vàng da, tiêu chảy, kiết lỵ, rong kinh, viêm nhiễm, tiểu đường và các vấn đề về tử cung… Ở Việt Nam, loài này được dùng để điều trị bỏng, thiếu mật, cầm máu và bệnh lậu. Nhiều nghiên cứu gần đây cho thấy loài này có nhiều hoạt tính như chống ung thư, kháng viêm, kháng khuẩn, hạ đường huyết, bảo vệ gan. Trong nghiên cứu này, hai lignan bao gồm matairesinol 4-O-β-D-glucopyranoside (1) và nortrachelogenin 4-O-β-D-gluopyranoside (2) đã được phân lập từ cặn chiết methanol của lá loài S.cochinchinensis bằng các phương pháp sắc ký hiện đại như sắc ký bản mỏng, sắc ký cột và sắc ký lỏng hiệu năng cao. Cấu trúc của các hợp chất đã được xác định thông qua phân tích các dữ liệu quang phổ khối ion hóa phun điện tử có độ phân giải cao (HR-ESI-MS), phổ 1D-NMR, phổ 2D-NMR và kết hợp so sánh với các dữ liệu phổ trong các tài liệu tham khảo. Các hợp chất 1 và 2 lần đầu tiên trên thế giới được phân lập từ loài S. cochinchinensis và từ chi Symplocos.

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