The objective of the present study was to develop a model for type 2 diabetes of rats. After 10 weeks received high fat diet (40 percent lipid) fed rats were injected intra peritoneally with low dose of streptozocin (STZ) (50mg kg -1). After 72h STZ injection were elevated body weight (64.27 percent), glucose (56.96 percent), triglyceride (33.02 percent), cholesterol (25.87 percent) in blood on experimental rats. The increasing body weight and disorder of glucose and lipid in blood of rats were the same disorder. of type 2 diabetes on patients.