Research objectives: To assess the treatment effects of Propranolol in esophageal varices due to cirrhosis. Subjects: 34 patients were diagnosed with esophageal varices due to cirrhosis in Digestive Internal Department of Hue Central hospital from October, 2006 to May, 2007. Methods: The patients were recorded the parameters of vessels, blood pressure, bleeding, arterial vein diameter by ultrasound and were assessed the levels of esophageal varices by endoscopy. Then they were treated with Propranolol to reduce heart rate 25 percents and blood pressure 20 mmHg compared to before treatment. They were used Propranolol during a month, then were tested all the parameters of bleeding, portal vein diameter and the levels of esophageal varices to assess the effects of treatment. Results: Propranolol helps to reduce portal vein diameter by ultrasound: portal vein diameter before the average treatment is 15.74 + or - 2.19 mm, after the average treatment is 13.26 + or - 2.19mm, the change was statistically significant, with p 0.05. Propranolol helps to reduce the size of esophageal varices by endoscopy: 7 patients (20.6 percent) reduced the level of esophageal varices, 26 patients (76.5 percent) kept the level of esophageal varices. Propranolol also helps to reduce the risk of bleeding due to rupture of esophageal varices: there were 9 patients (26.5 percent) bleeding before treatment, but after treatment, only 4 patients (11.8 percent) bleeding, the differences were statistically significant, with p 0.05. Response rate with Propranolol was 82.3 percent, in particular, good response rate was 20.6 percent, moderate response rate was 61.8 percent. No response rate was only 17.7 percent. Condusions: Through the effect to reduce the portal vein pressure, Propranolol reduces the portal vein diameter by ultrasound, the size of esophageal varices by endoscopy, and reduce the risk of bleeding due to rupture of esophageal varices.