Aim: To study the clinical characteristics of hospitalized children under 15 years old with chronic renal failure (CRF) in the Uro-nephrology Department of the National Hospital of Paediatrics. Methods: Retrospective descriptive study of 57 patients with CRF from 01/01/2008 to 31/12/2009 Results: The most common of clinical signs of CRF was fatigue (87.7 percent), oligo-anuria (71.9 percent), anorexia (66.7 percent). Oedema was only seen in 50.9 percent of patients with CRF. All patients with stage III, IV, V of CRF had anemia. 100 percent of children with CRF had staturo-ponderal delays, among them 52.6 percent of CRF children had the heigh -2SD, 78.9 percent of children with CRF had a weight reduction -3SD. Condusions: Oinical signs of CRF were often nonspecific, usually had staturo-ponderal delays. Anemia was always seen in patients with stage III, IV, V of CRF.