Four isoenergic feed pellets of different protein and lipid levels, namely 01 (35 percent Pr, 10 percent L), 02 (42 percent Pr, 10 percent L), 03 (42 percent Pr, 5 percent L) and 04 (35 percent Pr, 5 percent L), were used to investigate the growth of bagrid catfish Mystus nemurus in cages breed in water reservoir in Yen Thanh, Nghe An. Experimental fish of initial size of 47.0 + or - 1.2 g were fed twice a day to satiation in 85 days. Fish fed on diet 02 which contained the highest protein and lipid levels showed the best growth rate and the lowest feed conversion ratio (P 0.05). Fish fed on 04 diet with the lowest in protein and lipid content yielded the lowest growth rate and protein efficiency ratio and ths highest feed conversion ratio (P 0.05). Fish fed on diet 03 gave similar growth rate, protein efficiency ratio to those fed on diet 01 but had a lower feed conversion ratio (P 0.05). Survival rates of fish from all feed treatments were high (93.0-96.0 percent) and no significant difference was found among treatments. Based on these results, diet D2 (42 percent protein and 10 percent lipid) was recomended for maximizing growth rate and feed utilization of Mystus nemurus.