Identification of a novel population of neuromedin S expressing neurons in the ventral tegmental area that promote morphine-elicited behavior.

• Tác giả: M Alday, S Caico, N Camacho Fontánez, O Dodson, A Garrison, E A Heller, Q Hu, X Huang, M S Mazei-Robison, C Rivera Quiles, F Shafieichaharberoud, S C Simmons
• Ngôn ngữ: eng
• Ký hiệu phân loại: 594.38 *Pulmonata
• Thông tin xuất bản: United States : The Journal of neuroscience : the official journal of the Society for Neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 48217

Tóm tắt

Opioid use disorder constitutes a major health and economic burden, but our limited understanding of the underlying neurobiology impedes better interventions. Alteration in the activity and output of dopamine (DA) neurons in the ventral tegmental area (VTA) contributes to drug effects, but the mechanisms underlying these changes remain relatively unexplored. We used translating ribosome affinity purification and RNA sequencing to identify gene expression changes in mouse VTA DA neurons following chronic morphine exposure. We found that expression of the neuropeptide neuromedin S (