CHẾ TẠO HẠT NANO ASTAXANTHIN/PYCNOGENOL: MỘT HỆ THỐNG PHÂN PHỐI CẢI THIỆN ĐỘ ỔN ĐỊNH VÀ KHẢ DỤNG SINH HỌC CHO ASTAXANTHIN=PREPARATION OF ASTAXANTHIN/PYCNOGENOL NANOPARTICLES: A DELIVERY SYSTEM WITH IMPROVED ASTAXANTHIN STABILITY AND BIOAVAILABILITY

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Tác giả: Tien Dat Doan, Thi Nhung Hac, Thi Oanh Ho, Mai Ha Hoang, Duc Tuyen Nguyen, Hong Tham Nguyen, Thi Sang Nguyen, Yen Thanh Nguyen, Cong Doanh Truong

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học & Công nghệ - Trường Đại học Công nghiệp Hà Nội, 2024

Mô tả vật lý: tr.128

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ID: 482348

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Astaxanthin (AST) and pycnogenol (PYC) are natural bioactive compounds commonly used in pharmaceuticals and functional foods due to their highly antioxidant activity and potential health benefits. However, the widespread application of astaxanthin is hindered by its poor water solubility and highly unsaturated structure. In this study, nanoparticles co-delivering astaxanthin and pycnogenol (NAP) were fabricated to enhance the dispersibility, stability, and bioavailability of astaxanthin. The particle size, dispersion index, zeta potential (ζ), and morphology of the nanoparticles were characterized, revealing that the NAP were spherical, had a negative surface charge, and an average particle size in the range of 70 - 91nm with a narrow size distribution. X-ray diffraction (XRD) demonstrated that AST existed in an amorphous form within the NAP. Notably, the excellent water dispersibility and high stability of the astaxanthin/pycnogenol nanoparticles significantly enhanced cellular uptake, with absorption efficiency being 12 times higher than that of pure astaxanthin. Furthermore, the antioxidant activity was notably improved. These findings suggest that the astaxanthin/pycnogenol nanoparticles is an ideal formulation of astaxanthin, offering potential for the development of new functional foods.Astaxanthin (AST) và pycnogenol (PYC) là các hợp chất có hoạt tính sinh học tự nhiên thường được sử dụng trong dược phẩm và thực phẩm chức năng bởi hoạt tính chống oxy hóa cao và lợi ích tiềm năng của chúng đối với sức khoẻ. Tuy nhiên, việc ứng dụng rộng rãi astaxanthin bị hạn chế do khả năng hòa tan trong nước kém và cấu trúc không bão hòa cao. Trong nghiên cứu này, các hạt nano đồng phân phối astaxanthin và pycnogenol (NAP) đã được chế tạo để nâng cao khả năng phân tán, tính ổn định và sinh khả dụng cho astaxanthin. Kích thước hạt, chỉ số phân tán, thế zeta (ζ) và hình thái của các hạt nano đã được xác định, cho thấy rằng các hạt nano NAP có dạng hình cầu, có điện tích bề mặt âm và kích thước hạt trung bình trong khoảng từ 70 - 91nm với dải phân bố kích thước hẹp. Giản đồ nhiễu xạ tia X đã chứng minh rằng AST tồn tại ở dạng vô định hình trong các hạt nano NAP. Đặc biệt, khả năng phân tán tốt và tính ổn định cao trong nước của các hạt nano astaxanthin/pycnogenol đã tăng cường khả năng hấp thu vào trong tế bào một cách đáng kể, với hiệu quả hấp thu gấp 12 lần so với astaxanthin tự do. Ngoài ra, hoạt tính chống oxy hóa cũng được cải thiện đáng kể. Những kết quả này cho thấy rằng hệ nano astaxanthin/pycnogenol là một công thức bào chế lý tưởng của astaxanthin, mở ra tiềm năng phát triển các loại thực phẩm chức năng mới.

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