Nowadays allergy occupies a significant place in modern medicine, the world 15-20 percent of the population are allergic, of which 20 percent of patients susceptible to airway allergens. By 2015 there may be up to half the population have allergies. Allergens in house dust is one of the most common cause of the atopy disease, accounting for a large proportion of allergic rhinitis. Strategy for treatment of allergic rhinitis depends on four basic principles is to avoid exposure to allergens, drug treatment, specific immune therapy and educate patients. Specific immune have two main lines: subcutaneously (SCIT - Subcutaneous Immunotherapy) and small sugar under the tongue (Slit-Sublingual Immunotherapy). Subjects and methods: 120 patients were divided into 2 groups of specific immunotherapy injections and sublingual from 6 2010 - 6/2012, comparing the change of functional symptoms. Results and banluan: comparison of functional symptoms in two groups of patients VMDU by house dust mite allergen D. pte the authors found two methods are effective and equally clearly, there is no difference statistically significant (p 0.05).