Prognostic of the cancer is based TNM, the histologics and the cell-surface receptor (p53, Ki 67, EGFR-Epidermal Growth Factor Receptor (ErbB-1
HERI...). Ojective: The estimated measure EGFR and oporizied with the clinic and histopathologic of the cancer naso-sinusal. Materials and Methods: Case study of 32 patients operateds at Hospital ENT Central (2011-2012). Diagnostic clinical, CT scan, histopathologics of HE, PAS and immuno-histopathologic. Results and discussions: The EGFR is positive of 53.1 percent, positive (+++) 25 percent. 28/32 patiens of S III is positive of 50 percent (+), (+++) 21.4 percent. 4/32 patiens of S IV is positive of 75 percent, 50 percent (+++).The EGFR is more lositive of the forms vegetable growth, advanced, palsy of nerve cranium, nodule. Conclusion: The EGFR is positive of 53.1 percent of the cancer naso-sinusal.