Đặc điểm gen mã hóa mannan - binding lectin serine protease 1 ở lợn / Đặc điểm gen, kiểu hình và người lành mang gen bệnh tăng sản thượng thận bẩm sinh thiếu enzym 21 - hydroxylase / Đặc điểm giấc ngủ của trẻ đang điều trị bạch cầu cấp dòng lympho giai đoạn duy trì tại Bệnh viện Nhi Trung ương

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Tác giả: Ngọc Lan Bùi, Võ Anh Khoa Đỗ, Wimmers Klaus, Thị Bội Lê, Thị Phương Nguyễn, Thị Thanh Mai Nguyễn, Kim Hảo Trần, Thị Thương Lan Vũ

Ngôn ngữ: vie

Ký hiệu phân loại: 660610618.92 Chemical engineering and related technologies

Thông tin xuất bản: Công nghệ sinh học, Tạp chí nghiên cứu y học, Tạp chí Y học Việt Nam (Tổng hội Y học Việt Nam), 201220072023

Mô tả vật lý: 449-455, 109-116, 45421

Bộ sưu tập: Metadata

ID: 483150

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Complement system is activated by three different ways - classical, alternative and lectin pathways. In presense of carbohydrate on the surface of microbes, manose-binding lectin (MBL) binds to members of the MBL-serine protease family (MASPI, MASP2 and MASP3) to generate proenzymes activating C4, C2, and C3 of complement system via the lectin and alternative pathways. However, these serine proteases have not been identified in pig yet. Therefore, this study was mainly focused on sequencing of cDNA and analyzing of structural protein of MASP1 molecule in pig. It was indicated that 3,009 nucleotide of MASP1, cDNA encoding 699 deduced amino acids was sequenced. The MASP1 gene had 16 exons and its encode polypeptide protein contained rich-cysteine domains such as CUB1 (a.a 18-138, 121 a.a, 2 cysteine), EGF _CA (a.a 139-182,44 a.a, 6 cysteine), CUB2 (a.a 185-297, 113 a.a, 4 cysteine) in N-terminus, two CPP domains (CCPI: a.a 301-362, 62 a.a, 4 cysteine and CCPa.a 367-432, 66 a.a, 4 cysteine) at the center ofprotein and Tryp_SPc domain (a. a 448-691, 244 a.a, 7 cysteine) in C-terminus. The putative signal peptide, N-glycosylation sites, catalytic sites and cysteines were also highly conserved between human and pig. Compared with human, porcine MASP1 showed 88 percent identity at protein level. Additionally, three single nucleotide polymorphisms at loci 1.650A -- G (Asp -- Gly, ex on 12), 1.748C --T (Leu -- Phe, exon 13) and 1.807C -- T (exon 13) were also found in a population of Landrace breed. This is valuable information for breeding program towards disease resistance in pigs.Mô tả đặc điểm giấc ngủ ở trẻ mắc bạch cầu cấp dòng lympho đang điều trị giai đoạn duy trì. Phương pháp nghiên cứu nghiên cứu khảo sát 71 trẻ mắc bạch cầu cấp dòng lympho đang điều trị giai đoạn duy trì từ 2 - 10 tuổi, tại Trung tâm Ung thư - Bệnh viện Nhi Trung ương, sử dụng bảng hỏi Children's Sleep Habits Questionaire (CSHQ) cho trẻ từ 5-10 tuổi và bảng hỏi rút gọn Short Form - Children's Sleep Habit Questionnaire (SF-CSHQ) cho trẻ từ 2-4 tuổi. Kết quả 95,8% trẻ bạch cầu cấp giai đoạn duy trì có vấn đề về giấc ngủ. Các vấn đề giấc ngủ phổ biến được cha mẹ báo cáo là chống đối trước khi vào giấc ngủ, khởi phát giấc ngủ chậm, lo lắng về giấc ngủ, buồn ngủ ban ngày. Gần 1/2 số trẻ có thói quen trước giờ đi ngủ buổi tối phổ biến là xem Ipad/điện thoại (49,3%) với thời gian xem màn hình trung bình 2,4 ± 0,78 giờ. Trẻ cũng có thời lượng ngủ ít hơn và thời gian đi ngủ muộn hơn so với khuyến cáo cho giấc ngủ nhu cầu theo lứa tuổi. Kết luận Trẻ mắc bạch cầu cấp dòng lympho đang điều trị giai đoạn duy trì có tỷ lệ gặp các vấn đề về giấc ngủ rất cao. Do đó, việc đánh giá và kiểm soát các vấn đề về giấc ngủ là cần thiết khi điều trị giai đoạn duy trì cho trẻ mắc bạch cầu cấp dòng lympho.

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