Introduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by. detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for bone marrow candidate and organ candidate patients. Evidence suggests that matching unrelate donors and recipients for HLA-A, -B and DRBl loci is a peridiction for an improved outcome. Methods and materials: HLA-A, -B, DRBl from 761 Kinh Vietnamese and HLA-C, DQBl from 185 Vietnamese were typed by PCR-SSP method and the frequency of loci were estimated. Result: The most frequent alleles were A*02 (22.60), A*l1 (31.41), A*24 (18.33), A*33 (12.42), B*15 (23.52), B*46 (11.50), CW*01 (18.65), CW*03 (24.32), CW*07 (18.92, CW*08 (16.49), DRBl *09 (11.17), DRBl *12 (30.09), DRBl *15 (10.97), DQB1*02 (16.76), DQB1*03 (45.95), DQB1*05 (19.46), DQBl *06 (15.14), respectively. Discussion: The HLA typing data show similarity between neighbor and related countries in Southeat Asia. Identifying HLA alleles helps to find suitable donors for hematopoietic stem transplantation.