Studying heart rate disorder by 24 hours ECG holter of 139 patients with diabetic nephropathy compared to those of 108 type 2 diabetic meliitus without kidney injury and 30 healthy people, the results show that rate of heart rate variability is 71.2 percent. Rate of ventricular rate disorder of patients with diabetic nephropathy is significantly higher compared to those of diabetic patients without kidney injury, p 0.001. Ratio of atrial and ventricular rate disorder is positively related to stage of chronic kidney diaseses of type 2 diabetic patients with kidney injury, but no signifficantly p 0.05.