Excessive fluoride concentration in water leads to dental and skeletal fluorosis and lesions of the endocrine glands, thyroid and liver. High content of fluoride is mainly found in ground water and especially in wastewater from many major industrial branches. Removal of fluoride from industrial wastewater using adsorbents prepared from red mud was studied in this paper. Four adsorbents, which are the original neutralized red mud, the activated red mud at high temperature, the magnesium incorporated red mud and the cerium incorporated red mud, were investigated and compared. Batch adsorption experiments were conducted to study and optimized operational parameters including contact time and effect of co-ions. The removal of fluoride was expressed with Langmuir and Freundlich isotherms. The sufficient time for adsorption equilibrium of fluoride is around 1 hour. The activation forms of red mud enhanced adequately fluoride removal capacity in comparison with the original form.