The aim of this research was to study treatment municipal sewage sludge and organic waste by thermophilic anaerobic digestion. Along with experiments, the equipment as pilot scale was made and used. The experiments were implemented in the same condition with different ratio between municipal sewage sludge (MSS) and organic waste (OW). During experiments, the parameters like COD total, Nitrogen total (TN), Phosphorous (TP), V (biogas), biogas composition, pH, EC were tested. In comparison parameters of scenarios to found out the suitable ratio of weight between sewage sludge and organic waste in optimization of removing COD total (CODt), TN, TP as well as generating biogas. The results of this research play an important role to develop technology model of treatment municipal sewage sludge and organic waste. Specially, Vietnamese condition where organic waste as well as municipal sewage sludge had not paid more attention.