Perfluoroalkyl and poly-fluoroalkyl (PFAS) are synthetic organic compounds that are currently under scrutiny due to their high toxicity and potential to accumulate in the environment. To comply with EU 2020/2184 standards, the process for analyzing 21 PFAS compounds in water samples has been refined. Specifically, 250 mL of water undergoes pretreatment and enrichment using a weak anion exchange column (WAX) before being analyzed on the LC-MS/MS ABSciex Qtrap 4000 system. The method's detection limit (MDL) and limit of quantification (MQL) for the 21 PFAS compounds are 1 pg mL-1and 3 pg mL-1, respectively. Our validation results demonstrate high accuracy and precision, with a recovery efficiency ranging from 82 - 106%, and repeatability and reproducibility below 11%. Notably, upon analyzing 5 water samples, none of the 21 PFAS compounds were detected