Objectives: To indentify the allele frequency of HLA class I and class II loci. Patients and Method: HLA-A, HLA-B, HLA-DR of 290 Kinh Vietnamese were typed by PCR-SSP method and the frequency of loci were estimated. Results: The most frequent alleles were: A*l1, A*02, A*24, A*33
B*15, B*46
DRB1*12, DRB1*09, DRB1*15. Alleles A*34, A*36
B*08, B*14, B*28
DRB1*16, DRB1*01, DRB1*11 were rare appeared. Conclusion: the study showed the results similar with other Vietnamese authors.