Thử hiệu lực của vacxin navet-vifluvac phòng bệnh cúm a/h5n1 clade 1.1 và 2.3.2.1c bằng phương pháp công cường độc và tiếp xúc trực tiếp / Thử hiệu lực một số thuốc trị trypanosoma evansi qua thử nghiệm in vitro và in vivo / Thử hoạt tính sinh học và xác định hàm lượng jatrorrhizine bằng phương pháp LC/MS có trong thân cây mật gấu (Mahonia nepaulensis DC) ở Đại Từ

Thử hiệu lực của vacxin navet-vifluvac phòng bệnh cúm a/h5n1 clade 1.1 và 2.3.2.1c bằng phương pháp công cường độc và tiếp xúc trực tiếp / Thử hiệu lực một số thuốc trị trypanosoma evansi qua thử nghiệm in vitro và in vivo / Thử hoạt tính sinh học và xác định hàm lượng jatrorrhizine bằng phương pháp LC/MS có trong thân cây mật gấu (Mahonia nepaulensis DC) ở Đại Từ - Thái Nguyên

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Tác giả: Thị Vui Đàm, Thanh Thủy Đỗ, Thị Vân Giang Đỗ, Minh Lê, Thị Giang Lê, Hoàng Đăng Nguyễn, Thị Kim Lan Nguyễn, Thị Mỹ Ninh Nguyễn, Thị Ngân Nguyễn, Văn Quang Nguyễn, Diệu Thùy Phạm, Sĩ Tú Phạm, Thị Hồng Phúc Phan, Long Thành Tô, Thị Phấn Tô, Hữu Hiền Tống, Xuân Hạnh Trần

Ngôn ngữ: vie

Ký hiệu phân loại: 636636615 Animal husbandry

Thông tin xuất bản: Khoa học kỹ thuật thú y, Khoa học kỹ thuật thú y, Tạp chí Khoa học và Công nghệ Đại học Thái Nguyên, 201320132020

Mô tả vật lý: 22-29, 69-77, 271-276

Bộ sưu tập: Metadata

ID: 484035

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This study aimed at evaluating the efficacy of Navet-Vifluvac vaccine when challenge test with High Pathogen Avian Influenza Virus (HPAIV) of the high virulence strains: clade 1.1 and 2.3.2.1 c. The studied results showed that the immune chickens with Navet-Vifluvac vaccine were protected when challenge test with high virulence strains: clade 1.1 and clade 2.3.2.1 c after 3 weeks of vaccination. The relationship between titration (HI) and protection threshold was also identified in this study. Analysis of experimental results indicated that the chicken having titre HI or = 4log2 were protected at 100 percent when challenge test with strains: clade 1.1 and 2.3.2.1.c, even chicken having HI at lower level (2log2) were able to protect against these clades at 100 percent when challenge by direct contact way. From the checking result on HI titre of sera from chickens at 2 weeks old, it is suggested that inoculation of avian influenza vaccine for chickens at 2 weeks old can affect immune response in chicken.Trypanosoma evansiwas isolated from cattle, goats, horses in 6 provinces of Vietnam. It was tested to determine its efficacy to some medicines in vivo and in vitro conditions. The studied results showed that: Trypamidium samorin was a highest effective medicine for treating T. evansi
diminavet and azidin were the lower effective medicines to treatment of T. evansi
trypanosoma was the lowest effective medicine to kill T. evansi in vivo as well as on experimental white mice. In other words, T. evansi is very susceptive with trypamidium samorin medicine, lower susceptive with diminavet and azidin medicines, and resistant to trypanosoma medicine. Safety and treatment effectiveness were obtained when using a higher effective medicine dose than recommended dose of the manufacturer for testing experimental animals to disease caused by T. evansi.Cây mật gấu (Mahonia nepaulensis DC.) là một trong nhiều cây thuốc quý ở Việt Nam. Trong nộidung nghiên cứu này, nhóm tác giả đã tiến hành khảo sát các lớp chất, thử hoạt tính sinh học vàxác định hàm lượng jatrorrhizine có trong thân cây mật gấu. Các phương pháp nghiên cứu được sửdụng bao gồm phương pháp ngâm chiết để thu dịch chiết, phương pháp hóa học để khảo sát cáclớp chất từ dịch chiết cây mật gấu, phương pháp thử hoạt tính sinh học, phương pháp xây dựngđường chuẩn để xác định hàm lượng phần trăm jatrorrhizine. Kết quả cho thấy trong cặn chiếtethanol của thân cây mật gấu có alkaloids, steroids, coumarin, cardiac glycosides. Cặn chiếtethanol có khả năng kháng yếu đối với chủng nấm mốc Fusarium oxysporum (200 μg/mL), cặn nbutanolcó khả năng kháng yếu đối với chủng vi khuẩn Staphylococcus aureus (149,3 μg/mL).Hàm lượng jatrorrhizine có trong cây mật gấu là 0,682203%. Việc xác định hàm lượng, jatrorrhirine có trong thân cây mật gấu có ý nghĩa quan trọng trong việc mở ra hướng nghiên cứuthuốc chữa bệnh tiểu đường, bệnh vẩy nến và bệnh Alzheimer.

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