Đánh giá tác động giảm đau, kháng viêm của cao chiết nước cỏ Mần trầu (Eleusine indica (Linn.) Gaertner)=Anti-inflammatory and analgesic activity of aqueous extract of Eleusine indica (Linn.) Gaertner

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Gia Mẫn Đỗ, Thị Phương Liên Hoàng, Hữu Phúc Nguyễn, Thị Bạch Tuyết Nguyễn, Ánh Minh Trang Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2024

Mô tả vật lý: tr.43

Bộ sưu tập: Metadata

ID: 484248

Thêm vào giỏ

Nghiên cứu thực hiện nhằm đánh giá tác động giảm đau và kháng viêm in vivo của cao chiết nước phần trên mặt đất cỏ Mần trầu ở chuột nhắt trắng. Tiêm phúc mô dung dịch acid acetic 1 % để gây đau cho chuột, theo dõi số lần đau và thời gian đau trong vòng 40 phút. Ở thử nghiệm kháng viêm, chuột được tiêm dưới da gan bàn chân dung dịch carrageenan 1 %, theo dõi độ sưng phù bàn chân ở các thời điểm (3, 6, và 24) giờ sau khi tiêm. Thuốc đối chứng là diclofenac, 5 mg/kg thể trọng, đường uống. Chuột được uống cao chiết ở liều (250 và 500) mg/kg có số lần đau giảm (35,98 và 53,78) % và thời gian đau giảm (38,00 và 57,85) % so với lô chứng bệnh (p <
0,05). Ở thử nghiệm kháng viêm, lô chuột được uống cao chiết cỏ Mần trầu ở liều (250 và 500) mg/kg giảm độ sưng phù chân chuột (38,29 và 42,58) % ở thời điểm 24 giờ sau khi tiêm carragenan so với lô chứng bệnh uống nước cất (p <
0,05). Kết quả thử nghiệm cho thấy cao chiết nước cỏ Mần trầu có tác động giảm đau, kháng viêm trên mô hình thực nghiệm.The present study investigated the anti-inflammatory and analgesic effects of the aqueous extract of dried aerial parts of Eleusine indica (Linn.) Gaertner. The analgesic activity was evaluated in 1 % acetic acid-induced writhing test in mice. The writhing was counted and calculated the time of writhes within 40 minutes. The extracts was studied for its anti-inflammatory activity in carrageenan-induced hind paw edema mice and the paw volume was measured plethysmometrically at (3, 6, and 24) hours after injection. Diclofenac 5 mg/kg b.w., p.o. was used as a positive control. The extract at dosages of (250 and 500) mg/kg b.w., p.o. significantly reduced the number of writhes at (35.98 and 53.78) % and the time of writhes at (38.00 and 57.85) % (p <
0.05), respectively. The extract at doses of (250 and 500) mg/kg b.w., p.o treatment prevented carrageenan-induced inflammatory edema by (38.29 and 42.58) % when measured 24 hours following the carrageenan injection, respectively. The results of the study indicated that the aqueous extract of Eleusine indica (Linn.) Gaertner has anti-inflammatory and analgesic potentials that can be exploited in the management of pain and inflammatory conditions.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR