NGHIÊN CỨU TÍNH CHẤT Y SINH CỦA MÀNG SrTiO3:Er3+/ Yb3+ LÊN TITAN ĐỊNH HƯỚNG ỨNG DỤNG TRONG CẤY GHÉP Y SINH=INVESTIGATION OF THE BIOMEDICAL PROPERTIES OF SrTiO3:Er3+/ Yb3+ THIN FILMS ON TITANIUM FOR BIOMEDICAL IMPLANT APPLICATIONS

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Tác giả: Tiến Hà Lê, Thị Mai Anh Nguyễn, Thị Thanh Tuyền Nguyễn, Hùng Vượng Nguyễn Thị Thanh Tuyền Phạm, Quốc Tuấn Tạ, Văn Hướng Trần

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2024

Mô tả vật lý: tr.67 -72

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ID: 484513

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In this study, SrTiO3:Er3+/Yb3+ thin films on titanium were fabricated by the hydrothermal method at 200°C for biomedical implant applications. Rare earth ions Er3+ and Yb3+ were codoped into the SrTiO3 host matrix by fixing the Er3+ concentration and varying the Yb3+ concentration. The structure and properties of the films were characterized by X-ray diffraction (XRD), and scanning electron microscopy (SEM). The perovskite-structured material coating was annealed at 800°C. The material forms flake-like structures with a fairly uniform size, with a flake thickness of about 2-5 nm and a flake size of about 3-6 μm. Surface properties were investigated by contact angle measurement. The SrTiO3:Er3+/Yb3+ material exhibited significantly higher wettability compared to Ti. A confocal laser scanning microscope (CLSM) confirmed good adhesion of kidney cells to the test samples after 48 hours of culture. The results indicate that the SrTiO3:Er3+/Yb3+ thin films possess promising biomedical properties, making them suitable for biomedical implants.Trong nghiên cứu này, màng SrTiO3:Er3+ /Yb3+ phủ lên titan được chế tạo thành công bằng phương pháp thủy nhiệt ở 200°C cho mục đích cấy ghép y sinh. Các ion đất hiếm Er3+ và Yb3+ được đồng pha tạp vào màng nền SrTiO3 bằng cách cố định nồng độ Er3+ và thay đổi nồng độ Yb3+. Cấu trúc và tính chất của màng được đặc trưng bởi nhiễu xạ tia X (XRD), và ảnh hiển vi điện tử quét (SEM). Lớp phủ của vật liệu có cấu trúc perovskite được xử lý ở nhiệt độ 800°C. Vật liệu hình thành các màng vảy có kích thước khá đồng đều, có chiều dày thành vảy khoảng từ 2 - 5 nm và kích thước vảy khoảng 3 -6 μm. Tính chất bề mặt được khảo sát bằng phương pháp đo góc thấm ướt với vật liệu SrTiO3:Er3+ /Yb3+ có khả năng thấm ướt cao hơn vượt trội so với Ti. Kính hiển vi laser quét hội tụ đồng tiêu (CLSM) được sử dụng để kiểm tra trạng thái phân bố của tế bào và xác nhận tế bào thận chuột bám dính tốt trên mẫu thử nghiệm sau 48h nuôi cấy. Kết quả chỉ ra rằng, lớp màng SrTiO3:Er3+ /Yb3+ có tính chất y sinh tốt phù hợp cho mục đích ứng dụng làm vật liệu cấy ghép y sinh.

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