In this paper, the idea of a hybrid DoE-ANFlS tool based on the application of ANFlS in Design of Experiments is introduced. This is a combination between the traditional Full Factorial Orthogonal Array (OA) and a soft computing technique. An experiment carried out on a conventional turning operation shows that the accuracy of the proposed DoE-ANFIS tool is better than the traditional Response Surface Method. Nevertheless, the main effectiveness of this method is awaited to be revealed in the cases of non-linear MTMO systems with discrete, noisy data.