This article about medical solid waste management in Thai Nguyen National General Hospital, particularly the management of hazardous medical solid wastes. Based on the actual conditions and proposed some principal solutions to settle some existing problems on medical solid waste management. Strictly classify the medical solid waste at sources, collection, transportation and storage according to the Decision No. 43/2007/QD-BYT dated November 30, 2007 of the Vietnam Ministry of Health promulgating the Regulation on management of medical solid wastes. Proposal is applying bacteria sterilizing technology by microwave equipment which operation in normal pressure conditions in order to reduce the amount of infectious wastes must be treated to bring economic benefits and improve environmental protection in the hospital.