Background: The patients with traumatic brain injury have low points of Glasgow coma scale. Increased blood glucose can be considered as a dangerous sign of severe traumatic brain injury. High level blood glucose relate to the worse prognosis too. Objectives: Study of blood glucose concentrations in patients with severe traumatic brain injury and find the correlation between blood glucose with Glasgow Coma Scale in patients with severe traumatic brain injury. Subjects and Methods: 120 patients with severe traumatic brain injury treated at Hue Central Hospital, age or = 18. Results: 120patients, 104 males, 16 females, 18-39 years old: 82 patients, 40-60 years old: 31 patients, 60 years old: 7 patients. Group patients with Glasgow 3-6 points: 35 patients, Glasgow 7-8 points: 85 patients. Blood glucose in patients with Glasgow 3-6 points: 12.65 + or - 3.53 mmol/L and Glasgow 7-8 points: 10.77 + or - 3.04 mmol/L. Conclusions: In severe traumatic brain patients, high blood glucose level relate to the low Glasgow coma scale. High level blood glucose relate to the worse prognosis.