Real-world association between ivacaftor initiation and lung function variability: A registry study.

• Tác giả: Eleni-Rosalina Andrinopoulou, Elizabeth A Cromwell, Raksha Jain, Hancheng Li, Nicole Mayer-Hamblett, Wayne J Morgan, Josh Ostrenga, Anushka K Palipana, David J Pasta, Margaret Rosenfeld, Rhonda D Szczesniak, Jonathan Todd
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , 2025
• Bộ sưu tập: NCBI
• ID: 48507

Tóm tắt

BACKGROUND: Increased variability in forced expiratory volume in 1 s of % predicted (FEV METHODS: We utilized the Cystic Fibrosis Foundation Patient Registry (2008-2020) to quantify this association and identify risk factors of increased variability. Linear mixed effects models were used to compare pre- and post-ivacaftor initiation periods for established outcome measures of FEV RESULTS: The analysis cohort included 527 individuals. Across outcomes, FEV CONCLUSIONS: There was evidence that ivacaftor initiation reduces FEV