NGHIÊN CỨU TỔNG HỢP VÀ HOẠT TÍNH GÂY ĐỘC TẾ BÀO UNG THƯ CỦA DẪN XUẤT [(E)-N-BENZYL-N-(2-(CYCLOHEXYLAMINO)-2- OXOETHYL)-4-(4-((E)-2-((2R,4aR,9aR)-2,5-DIHYDROXY-1,1,4ATRIMETHYL-2,3,4,4a,9,9a-HEXAHYDRO-1H-XANTHEN-7-YL)VINYL)- 2,6-DIHYDROXYPHENYL)-2-METHYLB=SYNTHESIS OF CYTOTOXIC SCHWEINFURTHIN G DERIVATIVE [(E)-N-BENZYLN-(2-(CYCLOHEXYLAMINO)-2-OXOETHYL)-4-(4-((E)-2-((2R,4aR,9aR)-2,5- DIHYDROXY-1,1,4a-TRIMETHYL-2,3,4,4a,9,9a-HEXAHYDRO-1H-XANTHEN-7- YL)VINYL)-2,6-DIHYDROXYPHENYL)-2-METHYLBUT-2-ENAMIDE]

• Tác giả: Thị Mai Hương Đoàn, Thùy Linh Nguyễn, Văn Cường Phạm, Thị Đào Phí, Văn Hiệu Trần, Văn Nam Vũ
• Ngôn ngữ: vie
• Thông tin xuất bản: Tạp chí Phân tích Hóa, Lý và Sinh học, 2024
• Mô tả vật lý: tr.57-64
• Bộ sưu tập: Metadata
• ID: 485392

Tóm tắt

Schweinfurthin G, a stilbenoid, was originally identified and isolated from Macaranga alnifolia, which were also isolated from Macaranga tanarius growing in Vietnam in high yield. This compound exhibited a strong cytotoxicity against A549 and KB cell lines with the IC50 values of 0,80 μM and 0,6 μM, respectively. However, there are few papers reporting about total synthesis of this derivative. In this paper, we reported the synthesis of a new diamide derivative of schweinfurthin G from schweinfurthin G through six reaction steps and this compound exhibited a strong cytotoxicity against KB cancer cell line with an IC50 value of 4,4 μM.