Two Human Cases of Fatal Meningoencephalitis Associated with Potosi and Lone Star Virus Infections, United States, 2020-2023.

• Tác giả: Daniel Abenroth, Sai Varun Bethina, Yee Cheng, Charles Y Chiu, Kafaya Foresythe, Raja Rama Godasi, Raymond Grams, Holly R Hughes, Carlos Isada, Camilla Reese, Venice Servellita, Sukhman Sidhu, Neeharika Thottempudi, Asritha Tubati, Michael R Wilson, Kelsey Zorn
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.4588 Astronautics
• Thông tin xuất bản: United States : Emerging infectious diseases , 2025
• Bộ sưu tập: NCBI
• ID: 485589

Tóm tắt

We used clinical metagenomic next-generation sequencing of cerebrospinal fluid to investigate bunyavirus infections in 2 immunocompromised patients in the United States who had fatal meningoencephalitis. Potosi virus has been isolated from mosquito vectors and Lone Star virus from tick vectors. These findings highlight the power of metagenomic next-generation sequencing in broad-based, agnostic detection of emerging viral infections that test negative using conventional targeted diagnostic methods.