Knowledge-sharing plays a crucial role in the development of both individuals and organizations. In a university setting, this process is especially important, as it enhances students’ learning and research efficiency. Actively and voluntarily sharing knowledge not only helps students acquire more information but also facilitates the application of what they have learned to real-world scenarios later in life. This article aims to explore the factors influencing knowledge-sharing activities among university students by surveying 455 students in Can Tho City. Cronbach’s alpha coefficient was used to eliminate variables with low reliability, followed by exploratory factor analysis (EFA) to redefine the groups of variables in the research model. A regression analysis was then conducted to determine the factors impacting students' knowledge-sharing activities. The results indicate that factors such as Sociability, Trust, Information Technology, Instructor Support and Teamwork influence the knowledge-sharing activities of university students in Can Tho. Based on these findings, the study suggests several strategies to promote knowledge-sharing among university students.