A biosphere reserve is an area that includes terrestrial, marine, and/or coastal ecosystems or a combination of these, and is internationally recognized under UNESCO's Man and the Biosphere Programme (MAB). It is designated as part of the World Network of Biosphere reserves. In 1976, the World Network of Biosphere reserves was established by UNESCO. As of June 2023, the Network has 748 Biosphere reserves in 134 countries. Vietnam became a member of the World Network of Biosphere reserve and joined MAB in 2000 since the first Biosphere reserve, Can Gio mangrove forest, Ho Chi Minh City, was recognized by UNESCO. After 22 years, Vietnam has 11 Biosphere reserves, accounting for about 14.69% of the country's natural area, becoming the country with the second largest number of Biosphere reserves in Southeast Asia. The nomination and management of biosphere reserves are conducted in accordance with UNESCO's guidelines, while adhering to the legal regulations of the host country. The article provides information on UNESCO's regulations and guidelines, the legal frameworks governing the organization and management of Biosphere reserves in Vietnam, and offers recommendations for improving and implementing the management framework for Biosphere reserves in Vietnam in the future.