This study evaluated the antifungal activity against Malassezia furfur of Piper betle L. essential oil by agar diffusion assay. The inhibition zone diameter of P. betle essential oil was 21.7± 1.31mm (50 mg/mL), 14.1 ± 0.63 mm (25 mg/mL) and 10.2 ± 0.35 mm (12.5 mg/mL). However, essential oils have low solubility in water and are unstable by environmental factors. This study also developed the self-nanoemulsifying drug delivery system (SNEDDS) containing P. betle essential oil to enhance its stability and solubility. The composition of the nanoemulsion included P. betle essential oil (1 % v/v) and capric triglyceride (1 % v/v) as the dispersion phase, distilled water (92 % v/v) as the continuous phase, non-ionic surfactant Tween 80 (4.8 % v/v) along with 1,3-propanediol (1.2 % v/v) as the emulsifying agents. Dynamic light scattering (DLS) measurements showed that the P. betle nanoemulsion had a mean droplet size that meets the size requirements of the SNEDDS and remained relatively stable for 42 days of storage. In comparison, the minimum inhibitory concentration (MIC) of P. betle essential oil in the nanoemulsion against M. furfur was 0.625 mg/mL, twice as high as the MIC of P. betle essential oil dissolved in DMSO. In conclusion, the nanoemulsion containing P. betle essential oil has potential applications in antifungal activity against M. furfur. However, the stability in antifungal ability of nanoemulsion needs to be determined more clearly in future studies.