Đặc điểm lâm sàng và bệnh lý của chó mắc biến thể CPV-2C mới tại Việt Nam=Clinical and pathological characterization of a novel canine parvovirus type 2c variant in dogs in Viet Nam

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Tố Nga Bùi, Văn Hải Võ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2024

Mô tả vật lý: tr.14

Bộ sưu tập: Báo, Tạp chí

ID: 486489

Thêm vào giỏ

Canine parvo virus type 2 (CPV-2) gây bệnh viêm ruột tiêu chảy cấp tính ở chó nuôi dẫn đến tử vong trên phạm vi toàn thế giới. CPV-2 hiện hữu đa dạng các biến thể, với nhiều kiểu gen khác nhau và xuất hiện dần theo thời gian. Trong những năm gần đây, một biến thể mới CPV-2c xuất hiện và đã trở nên phổ biến tại Việt Nam. Tuy nhiên, cho đến nay vẫn chưa có nghiên cứu nào khảo sát các đặc điểm bệnh lý lâm sàng của bệnh do biến thể mới này gây ra trên chó. Trong nghiên cứu này, chúng tôi nghiên cứu các đặc điểm lâm sàng và bệnh lý của biến thể mới (“new-var”) tại Việt Nam. Kết quả nghiên cứu cho thấy có 43 ca dương tính với biến thể CPV-2c. Biểu hiện lâm sàng của chó khi mắc bệnh CPV-2c bao gồm mệt mỏi, nôn mửa, chán ăn, sốt, đặc biệt là tiêu chảy ra máu chiếm tỷ lệ 60,47% trong tổng số ca bệnh trong nghiên cứu này. Kết quả mổ khám đã ghi nhận có các tổn thương nghiêm trọng trên hệ thống tiêu hoá. Bệnh tích vi thể tập trung chủ yếu ở đường tiêu hóa như xung huyết, xuất huyết dạ dày, hạch màng treo
tế bào biểu mô ruột hoại tử, lông nhung đứt nát. 9/9 cơ quan trong nghiên cứu đều dương tính với kháng nguyên của CPV-2c bằng phương pháp nhuộm hoá mô miễn dịch. Những phát hiện trên nhấn mạnh sự thay đổi độc lực của chủng CPV-2c và tầm quan trọng trong việc giám sát để nhận biết các biến thể mới nổi cũng như tối ưu hoá chiến lược quản lý bệnh.Canine parvovirus type 2 (CPV-2) is a highly contagious pathogen causing fatal enteric and myocardial diseases in domestic dogs in the worldwide. CPV-2 exhibits genetic variations, with different genotypes emerging over time. In recent years, a new CPV-2c variant named "new-var" has become popularly in Viet Nam. Despite its prevalence, a comprehensive survey of the variant's prevalence and clinical-pathological characteristics is lacking. This study investigated the clinical and pathological features of the emerging CPV-2 "new-var" in Viet Nam. The studied result showed that there were 43 cases positive with the canine parvovirus type 2c (CPV-2c) variant. The clinical manifestations of dogs with CPV-2c disease included lethargy, vomiting, loss of appetite, fever, especially bloody diarrhea, accounting for 60.47% of the total cases in this study. The result of autopsy revealed that there were the severe gastrointestinal and systemic lesions, suggesting that more impactful disease manifestations compared to previous CPV-2c strains. Histological lesions were concentrated mainly in the digestive tract, such as congestion, hemorrhage in the stomach and mesenteric lymph nodes, necrotic intestinal epithelial cells, and broken villi. 9/9 organs of dogs in the study were positive with CPV-2c antigen by immunohistochemistry method. These findings underscore the dynamic evolution of CPV-2 strains and emphasize the importance of continuous surveillance to address emerging viral variants and optimize disease management strategies.

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