Nghiên cứu tác dụng ức chế alpha glucosidase và acetylcholinesterase của cây Cỏ sao (Stellaria media L., Caryophyllaceae) thu hái tại Hải Phòng=Study on the inhibition of alpha-glucosidase and acetylcholinesterase by Stellaria media harvested in Hai Phong

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Tác giả: Thị Thùy Dung Hà, Thị Thu Huyền Lưu, Thị Quỳnh Mai Ngô

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học Sức khỏe, 2024

Mô tả vật lý: tr.46

Bộ sưu tập: Metadata

ID: 486640

Thêm vào giỏ

Nghiên cứu được thực hiện trên cây Cỏ Sao (Stellaria media L., Caryophyllaceae) thu hái tại Hải Phòng. Mẫu nghiên cứu được khảo sát thành phần hóa học bằng các phản ứng hóa học đặc trưng, phương pháp sắc ký lớp mỏng và thử hoạt tính ức chế enzyme alpha-glucosidase và acetylcholinesterase để đánh giá tiềm năng của dược liệu trong điều trị các bệnh lý liên quan. Kết qủa thu được phát hiện sự có mặt của carotenoid và glycoside tim, trong khi các nhóm chất như alkaloid, flavonoid, phytosterol, và saponin không được phát hiện. Sắc ký lớp mỏng sử dụng hệ dung môi n-hexan : ethyl acetate = 5 : 1 cho thấy phân đoạn ethyl acetate có nhiều vết rõ ràng hơn so với các phân đoạn khác. Cao toàn phần và các phân đoạn dược liệu không có hoặc có rất ít hoạt tính ức chế enzyme acetylcholinesterase (IC50 >
256 µg/ml). Hoạt tính ức chế enzyme alpha-glucosidase cũng rất yếu, với giá trị IC50 >
256 µg/ml. Tuy nhiên, dược liệu vẫn có tiềm năng nghiên cứu thêm về các đặc tính sinh học khác như bảo vệ tế bào và sức khỏe tim mạch.This study was conducted on ”Cỏ sao” (Stellaria media L., Caryophyllaceae) collected in Hai Phong. The chemical composition of the samples was analyzed using specific chemical reactions, thin-layer chromatography (TLC), and the inhibitory effects on alpha-glucosidase and acetylcholinesterase enzymes were tested to evaluate the potential of the herbal material in the treatment of related diseases. The results revealed the presence of carotenoids and cardiac glycosides, while groups such as alkaloids, flavonoids, phytosterols, and saponins were not detected. TLC using a solvent system of n-hexane : ethyl acetate (5:1) showed that the ethyl acetate fraction displayed more distinct and diverse spots than other samples, indicating the presence of various chemical compounds. The herbal samples exhibited little inhibitory activity on the acetylcholinesterase enzyme (IC50 >
256 µg/ml). Similarly, the inhibitory activity on the alpha-glucosidase enzyme was also fragile, with an IC50 value >
256 µg/ml. However, the herbal material still has the potential for further research on other biological properties, such as cell protection and cardiovascular health.

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